RECRUITING

Inflammatory Challenge and Fear

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who receive a placebo saline vaccine? Do people who receive typhoid vaccine experience changes in how they think and feel? Participants will: Attend four appointments at the San Francisco VA Health Care System; Receive typhoid vaccine or placebo at one of the visits; Have their physiological responding measured while listening to sounds; Complete questionnaires and psychological tests.

Official Title

Inflammatory Challenge and Fear Extinction: A Model to Enhance Understanding of Posttraumatic Stress Disorder

Quick Facts

Study Start:2025-03-28
Study Completion:2028-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06630884

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:25 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Aged 25-45 years old
  2. 2. Trauma Exposed
  3. 3. Current PTSD/No history of PTSD
  1. 1. Contraindications to typhoid vaccine
  2. 2. Conditions associated with inflammation
  3. 3. Pregnancy or plans to become pregnant in next three months
  4. 4. Lack of skin conductance response to breathing and arithmetic tasks at screening visit

Contacts and Locations

Study Contact

Aoife O'Donovan, PhD
CONTACT
415-221-4810
aoife.odonovan@ucsf.edu
Michael Srouji, BA
CONTACT
415-221-4810

Principal Investigator

Aoife O'Donovan, PhD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

San Francisco VA Health Care System
San Francisco, California, 94121
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Aoife O'Donovan, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-28
Study Completion Date2028-11

Study Record Updates

Study Start Date2025-03-28
Study Completion Date2028-11

Terms related to this study

Keywords Provided by Researchers

  • PTSD
  • posttraumatic stress
  • inflammation
  • fear

Additional Relevant MeSH Terms

  • Posttraumatic Stress Disorder (PTSD)