FIT Exercise in 30d of ULLS-induced Muscle Disuse

Description

This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical de-conditioning including loss of voluntary muscle strength, aerobic capacity, and balance regulation.

Conditions

Muscle Atrophy, Muscle Weakness

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Study Details

Study overview

This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical de-conditioning including loss of voluntary muscle strength, aerobic capacity, and balance regulation.

Use of Velocity Monitoring to Prescribe Appropriate Flywheel-based Inertial Training (FIT) Workloads for Exercise in Space Flight

FIT Exercise in 30d of ULLS-induced Muscle Disuse

Condition
Muscle Atrophy
Intervention / Treatment

-

Contacts and Locations

Lexington

University of Kentucky, Lexington, Kentucky, United States, 40506

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Regularly engaging in aerobic exercise (\> 150min/wk) and resistance exercise (\>1 time per week) for the past 12 months
  • * Education greater than or equal to bachelor's degree (any field)
  • * Waist circumference \< 55cm or \> 90cm (F) and \< 75cm or \> 100cm (M)
  • * Body mass index \< 18.5 or \> 29.9
  • * Shoe size \< 25 or \>29cm.
  • * Not regularly engaging in exercise for previous 12 months
  • * Tobacco use within previous 6 months
  • * Blood clotting disorder
  • * Heart arrhythmia
  • * Implanted device which could negatively be affected by electrical impulse or strong magnetic field such as pacemaker, internal defibrillator, or cochlear implant
  • * Diagnosed cardiovascular, pulmonary, renal, or metabolic disease
  • * Pregnancy (within previous 6 months)
  • * Oral contraceptive use (within previous three months)
  • * High resting blood pressure (\>140 systolic and/or \> 90 diastolic)
  • * Currently or previously undergone gender-affirming therapy (hormone therapy or sexual reassignment surgery)
  • * Low back or leg injury in previous 6 months
  • * Currently taking medication to assist with sleep
  • * Muscle, bone, or joint injury that limits physical activity within previous 6 months
  • * Neurological disorder which affects balance (such as multiple sclerosis or Parkinson's disease)

Ages Eligible for Study

35 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Lance Bollinger,

Lance Bollinger, PhD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

2025-09-01