RECRUITING

Neoadjuvant Darolutamide and Relugolix Combination Preceding Radical Prostatectomy for Prostate Cancer

Conditions

Prostate CA Prostate Cancer (Adenocarcinoma)Prostate Cancer Surgery Prostate Cancer High-Risk Prostate Cancer Neoadjuvant Therapy Radical Prostatectomy Darolutamide Relugolix Androgen Receptor Antagonists Gonadotropin-Releasing Hormone Antagonists Clinical Trial Phase I/Ib PSA Response

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to determine the safety and feasibility of a new combination of darolutamide and relugolix as neoadjuvant therapy preceding radical prostatectomy (RP) for high-risk prostate cancer (PCa) in adult males.

Official Title

Neoadjuvant Darolutamide and Relugolix Combination Preceding Radical Prostatectomy for High Risk Localized and Locally Advanced Prostate Cancer: A Phase I/Ib Trial

Quick Facts

Study Start:2024-10-22

Study Completion:2026-06

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06631521

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:MALE

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Histologically or cytologically confirmed adenocarcinoma of the prostate 2. ECOG performance status 0-1 3. Ability to swallow oral medications and comply with study procedures and requirements. 4. Males ≥18 years 5. Participants must have adequate organ and marrow function as below: 1. Absolute neutrophil count (ANC) ≥1,500/mm3 or ≥1.5 x 109/L; 2. Platelets ≥100,000/mm3 or ≥100 x 109/L; 3. Hemoglobin ≥8 g/dL (may have been transfused). 4. Estimated creatinine clearance ≥30 mL/min as calculated using the Cockcroft-Gault equation. 5. Total serum bilirubin \&amp;lt;1.5 x upper limit of normal (ULN), less than 2.0 x ULN if suspected Gilbert's syndrome; 6. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 2.5 x ULN. 6. Must be a candidate for RP 7. Clinical stage cT2-4, N0-1 8. Mandatory to identify tumor availability (≥10 FFPE slides, 5 µM thickness \& 1 stained H\&E slide OR tumor block) 9. High-risk PCa defined as one of the following- * Gleason score (GS) ≥ 4 + 3 with ≥ 6 positive systematic biopsies (SB) * GS ≥ 4 + 3 with ≥ 3 SB and prostate-specific antigen (PSA) ≥ 20 ng/mL * GS ≥ 9 in ≥ 1 SB or targeted biopsies (TB) -≥ 2 SB or TB with continuous GS ≥ 8, each with ≥ 80% involvement.	1. Histologic variants including neuroendocrine differentiation, small cell, sarcomatoid, ductal adenocarcinoma, squamous or transitional cell carcinoma) comprising more than 50% of the sample as determined by pathology review 2. Participants who have had chemotherapy or radiotherapy within 4 weeks prior to planned cycle 1 day 1 of study treatment. 3. Participants who have received anti-neoplastic intervention or experimental antineoplastic therapy within 14 days of planned cycle 1 day 1 of study therapy. 4. Participants who are receiving any other investigational agents. 5. Participants who have previously received darolutamide, relugolix, LHRH agonist/antagonist or another novel androgen blocking therapy (abiraterone, apalutamide, enzalutamide) within 1 year are excluded (prior bicalutamide that was discontinued ≥14 days prior to planned cycle 1 day 1 is allowed). 6. Participants who have not recovered from adverse events due to prior anti-cancer therapy (i.e. have residual toxicities ≥Grade 2) with the exception of alopecia. 7. Any of the following within 6 months before planned cycle 1 day 1 of study therapy: * Stroke * Myocardial infarction * Severe/unstable angina pectoris * Coronary/peripheral artery bypass graft * Congestive heart failure New York Heart Association (NYHA) Class III or IV. 8. Known or suspected contraindications, hypersensitivity or allergy to darolutamide or relugolix or to any of their excipients. 9. Participants with hepatitis C, hepatitis B or human immunodeficiency (HIV) who are on anti-viral therapy that has the potential to interact with darolutamide or relugolix. 10. Participants treated with drugs known to be strong inhibitors and/or inducers of cytochrome P450 3A4 (CYP3A4) and the treatment cannot be discontinued or switched to a different medication at least 5 half-lives prior to starting study drug. 11. NOTE: precaution is warranted with concomitant use of agents with a narrow therapeutic index that are substrates of P-gp, BCRP and OCT1. 12. The participant has serious and/or uncontrolled preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study (for example, interstitial lung disease, severe dyspnea at rest or requiring oxygen therapy, severe renal impairment \[e.g. estimated creatinine clearance less than 30ml/min\], history of major surgical resection involving the stomach or small bowel, or preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition resulting in baseline Grade 2 or higher diarrhea). 13. Concurrent active malignancy whose natural history or treatment has the potential to interfere with safety or efficacy assessment of the investigational regimen. Patients with non-melanomatous skin cancer, superficial bladder cancer, cancer not needing active therapy for at least 2 years, cancer for which the treating investigator deems the subject to be in remission, or any prior malignancy that was treated with curative intent (no evidence of disease for at least 3 years) are permitted to enroll.

Inclusion Criteria

Exclusion Criteria

1. Histologically or cytologically confirmed adenocarcinoma of the prostate
2. ECOG performance status 0-1
3. Ability to swallow oral medications and comply with study procedures and requirements.
4. Males ≥18 years
5. Participants must have adequate organ and marrow function as below:
1. Absolute neutrophil count (ANC) ≥1,500/mm3 or ≥1.5 x 109/L;
2. Platelets ≥100,000/mm3 or ≥100 x 109/L;
3. Hemoglobin ≥8 g/dL (may have been transfused).
4. Estimated creatinine clearance ≥30 mL/min as calculated using the Cockcroft-Gault equation.
5. Total serum bilirubin \&amp;lt;1.5 x upper limit of normal (ULN), less than 2.0 x ULN if suspected Gilbert's syndrome;
6. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) less than 2.5 x ULN.
6. Must be a candidate for RP
7. Clinical stage cT2-4, N0-1
8. Mandatory to identify tumor availability (≥10 FFPE slides, 5 µM thickness \& 1 stained H\&E slide OR tumor block)
9. High-risk PCa defined as one of the following-
* Gleason score (GS) ≥ 4 + 3 with ≥ 6 positive systematic biopsies (SB)
* GS ≥ 4 + 3 with ≥ 3 SB and prostate-specific antigen (PSA) ≥ 20 ng/mL
* GS ≥ 9 in ≥ 1 SB or targeted biopsies (TB) -≥ 2 SB or TB with continuous GS ≥ 8, each with ≥ 80% involvement.

1. Histologic variants including neuroendocrine differentiation, small cell, sarcomatoid, ductal adenocarcinoma, squamous or transitional cell carcinoma) comprising more than 50% of the sample as determined by pathology review
2. Participants who have had chemotherapy or radiotherapy within 4 weeks prior to planned cycle 1 day 1 of study treatment.
3. Participants who have received anti-neoplastic intervention or experimental antineoplastic therapy within 14 days of planned cycle 1 day 1 of study therapy.
4. Participants who are receiving any other investigational agents.
5. Participants who have previously received darolutamide, relugolix, LHRH agonist/antagonist or another novel androgen blocking therapy (abiraterone, apalutamide, enzalutamide) within 1 year are excluded (prior bicalutamide that was discontinued ≥14 days prior to planned cycle 1 day 1 is allowed).
6. Participants who have not recovered from adverse events due to prior anti-cancer therapy (i.e. have residual toxicities ≥Grade 2) with the exception of alopecia.
7. Any of the following within 6 months before planned cycle 1 day 1 of study therapy:
* Stroke
* Myocardial infarction
* Severe/unstable angina pectoris
* Coronary/peripheral artery bypass graft
* Congestive heart failure New York Heart Association (NYHA) Class III or IV.
8. Known or suspected contraindications, hypersensitivity or allergy to darolutamide or relugolix or to any of their excipients.
9. Participants with hepatitis C, hepatitis B or human immunodeficiency (HIV) who are on anti-viral therapy that has the potential to interact with darolutamide or relugolix.
10. Participants treated with drugs known to be strong inhibitors and/or inducers of cytochrome P450 3A4 (CYP3A4) and the treatment cannot be discontinued or switched to a different medication at least 5 half-lives prior to starting study drug.
11. NOTE: precaution is warranted with concomitant use of agents with a narrow therapeutic index that are substrates of P-gp, BCRP and OCT1.
12. The participant has serious and/or uncontrolled preexisting medical condition(s) that, in the judgment of the investigator, would preclude participation in this study (for example, interstitial lung disease, severe dyspnea at rest or requiring oxygen therapy, severe renal impairment \[e.g. estimated creatinine clearance less than 30ml/min\], history of major surgical resection involving the stomach or small bowel, or preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition resulting in baseline Grade 2 or higher diarrhea).
13. Concurrent active malignancy whose natural history or treatment has the potential to interfere with safety or efficacy assessment of the investigational regimen. Patients with non-melanomatous skin cancer, superficial bladder cancer, cancer not needing active therapy for at least 2 years, cancer for which the treating investigator deems the subject to be in remission, or any prior malignancy that was treated with curative intent (no evidence of disease for at least 3 years) are permitted to enroll.

Contacts and Locations

Study Contact

AdventHealth Oncology Research

CONTACT

407-303-2090

CFD.ResearchOncology@AdventHealth.com

Study Locations (Sites)

AdventHealth Orlando

Orlando, Florida, 32803

United States

Collaborators and Investigators

Sponsor: AdventHealth

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-22

Study Completion Date2026-06

Study Record Updates

Study Start Date2024-10-22

Study Completion Date2026-06

Terms related to this study

Keywords Provided by Researchers

Prostate Cancer
High-Risk Prostate Cancer
Neoadjuvant Therapy
Radical Prostatectomy
Darolutamide
Relugolix
Androgen Receptor Antagonists
Gonadotropin-Releasing Hormone Antagonists
Clinical Trial Phase I/Ib
PSA Response

Additional Relevant MeSH Terms

Prostate CA
Prostate Cancer (Adenocarcinoma)
Prostate Cancer Surgery