RECRUITING

Efficacy of Nanodropper-mediated Topical Anesthetic

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a "Nanodropper" adaptor. The Nanodropper is designed to administer smaller-sized drops, or microdrops. Participants will: 1. Complete a baseline eye exam. 2. Receive a numbing drop using a standard dropper in one eye and the Nanodropper in the other eye. 3. Have their eyes tested for numbness at specific time points (30 seconds, 1, 2, 5, and 10 minutes after getting the drops). 4. Tell the researchers if they feel pain during the eye sensation tests. 5. Complete a survey about their experience with the eyedrops and testing procedure. This study could help us find a way to use less medication while still effectively administering eye medications, potentially saving money and reducing medical waste.

Official Title

Evaluation of Nanodropper-mediated Microdrops vs. Standard Drops of 0.5% Proparacaine HCl

Quick Facts

Study Start:2024-12-12
Study Completion:2025-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06636708

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Ability to provide informed consent for topical anesthesia delivery
  2. 2. Ability to verbally respond to pain
  3. 3. At least 18 years of age
  1. 1. Have a contraindication to local anesthetics
  2. 2. History of intravitreal injections
  3. 3. History of ocular surgery
  4. 4. History of vitreous or retinal surgery
  5. 5. Preexisting diagnosis of ocular surface disease requiring punctal plug placement
  6. 6. Evidence of any current ocular inflammation
  7. 7. Any previous ocular condition (i.e., neurotrophic keratitis, herpetic eye disease, presence of a corneal graft, etc.) that has permanently altered the native sensation of the ocular surface
  8. 8. Use of contact lenses in the past year
  9. 9. Use of exclusionary medications: Topical steroid drops, non-steroidal anti-inflammatory drops, intraocular pressure lowering eye drops, any anti-viral medications used for herpes, opioids

Contacts and Locations

Study Contact

Aakriti G Shukla, MD MSc
CONTACT
212-305-9535
ag2965@cumc.columbia.edu
Charu Vyas, BA
CONTACT
cv2427@cumc.columbia.edu

Study Locations (Sites)

Columbia University Irving Medical Center
New York, New York, 10032
United States

Collaborators and Investigators

Sponsor: Columbia University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-12
Study Completion Date2025-12-01

Study Record Updates

Study Start Date2024-12-12
Study Completion Date2025-12-01

Terms related to this study

Keywords Provided by Researchers

  • Corneal anesthesia
  • Nanodropper

Additional Relevant MeSH Terms

  • Corneal Diseases
  • Effectiveness of Microdrops