Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity

Description

Metformin is the most prescribed blood sugar (glucose)-lowering medication for patients diagnosed with type 2 diabetes mellitus (T2DM). Metformin stimulates glucose uptake in skeletal muscle similar to the effects of exercise, though, some studies report that metformin may decrease exercise capacity. The main question this study looks to answer is: • Does metformin alter exercise capacity? Participants will: * Complete 5 exercise tests on a stationary bike. * Undergo a body composition test. * Take metformin and placebo. * Complete food and symptom logs. The researchers hypothesize that: • Metformin will reduce aerobic capacity.

Conditions

Exercise Capacity, Metformin

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Study Overview

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Study Details

Study overview

Metformin is the most prescribed blood sugar (glucose)-lowering medication for patients diagnosed with type 2 diabetes mellitus (T2DM). Metformin stimulates glucose uptake in skeletal muscle similar to the effects of exercise, though, some studies report that metformin may decrease exercise capacity. The main question this study looks to answer is: • Does metformin alter exercise capacity? Participants will: * Complete 5 exercise tests on a stationary bike. * Undergo a body composition test. * Take metformin and placebo. * Complete food and symptom logs. The researchers hypothesize that: • Metformin will reduce aerobic capacity.

Short-Term Metformin Use in Young, Healthy Adults: Impacts on the Blood Lactate Response to Exercise and Time-to-exhaustion in a Placebo-controlled, Crossover Study

Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity

Condition
Exercise Capacity
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia, Charlottesville, Virginia, United States, 22903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-30 years old
  • * Metformin-naïve
  • * BMI \< 30 kg/m2
  • * Recreationally active (≥ 3 days/week of exercise)
  • * Females must be premenopausal and report normal menstrual cycles
  • * Willingness and ability to comply with scheduled visits and study procedures.
  • * History of cardiometabolic disease, such as type 1 or type 2 diabetes
  • * Smoking (must have quit at least 6 mos prior)
  • * Use of medication that significantly alters glucose regulation (e.g., metformin, insulin, GLP-1 receptor agonists, SGLT-2 inhibitors, biguanides)
  • * Severe liver or kidney disease, or medications to treat liver or kidney disease
  • * Pregnant, breastfeeding, or plans to become pregnant during study period

Ages Eligible for Study

18 Years to 30 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Virginia,

Jason D Allen, PhD, PRINCIPAL_INVESTIGATOR, University of Virginia

Study Record Dates

2025-05-01