Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

Description

The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the participant surgical incision. The investigators hope to discover if providing numbing medication to a nerve that controls pain in a larger area of the knee (a nerve block), might be better at post-operative pain control.

Conditions

Tibial Plateau Fractures

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Study Overview

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Study Details

Study overview

The investigators are conducting this research study to find better ways of treating pain following knee surgery. There is a standard (accepted) approach, which involves injection of numbing medication into the area around the participant surgical incision. The investigators hope to discover if providing numbing medication to a nerve that controls pain in a larger area of the knee (a nerve block), might be better at post-operative pain control.

Genicular Nerve Block for Analgesia After Open Reduction Internal Fixation of Tibial Plateau Fractures: A Prospective, Randomized Controlled Trial

Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau

Condition
Tibial Plateau Fractures
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects younger than 18
  • * Polytraumatized Subjects
  • * Subjects with pathologic fractures
  • * Subjects with tibial plateau fractures treated nonoperatively
  • * Subjects with tibial plateau fractures treated operatively but with re-operations at the same site
  • * Subjects with open fractures
  • * Subjects with fracture-dislocations
  • * Subjects with active or history of anxiety
  • * Subjects with visual analog scale anxiety score ≥ 7 measured preoperatively
  • * Subjects with chronic pain syndromes
  • * Subjects with chronic opioid use
  • * Subjects with illicit drug use disorder
  • * Subjects with alcohol abuse disorder
  • * Subjects with kidney disease precluding use of ketorolac
  • * Subjects with liver disease precluding the use of acetaminophen
  • * Subjects with allergy to acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), opiates or local anesthesia
  • * Subjects with inability to provide a visual analog scale score postoperatively
  • * Subjects with contraindications to receiving peripheral nerve blocks, including relevant neurologic deficits, active infection at sites of injections - re-operation at the same site

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Chicago,

Anthony Christiano, MD, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

2026-06-14