Feasibility of Accelerated, Personalized rTMS as an Adjuvant for Impulse Control Disorders: a Pilot Study

Eligibility Criteria

• 1. Age 18 to 60
• 2. BMI\>30 (confirmed at in person visit)
• 3. Able to follow verbal and written instructions in English and complete all aspects of the study.
• 4. Have an address and telephone number where they may be reached.
• 5. Participants must report current stable residence. Stable residence is a domicile in which an individual can operate as if it were their own homestead and does not include shelters, halfway houses, treatment centers, or group homes.
• 6. Meet safety criteria for EEG and rTMS.
• 7. Provides written informed consent and agree to all assessments and study procedures.
• 8. Agrees to complete telehealth (live audio-video conference and phone) and in-person visits and to be contacted via text.
• 1. History of seizure, epilepsy, syncope, fainting episode, or head trauma resulting in loss of consciousness lasting over 15 minutes or with sequelae lasting longer than one week
• 2. Presence or history of neurological disorders (migraine, stroke, Alzheimer's Disease and other Dementias, Parkinson's Disease, Multiple Sclerosis, Traumatic Brain Injury (TBI), increased intracranial pressure).
• 3. History of brain surgery, implanted electronic device, metal in the head.
• 4. First-degree family history of epilepsy, schizophrenia, depression, or bipolar disorder.
• 5. Cardiac pacemakers, neural stimulators, implantable defibrillator, implanted medication pumps or sensors, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object in the body.
• 6. rTMS exposure for treatment or research purposes in the last 6 months.
• 7. History of or currently under medical care for myocardial infarction, angina, congestive heart failure, cardiomyopathy, stroke, or transient ischemic attack.
• 8. Reports current diagnosis or history of type I diabetes.
• 9. Currently using insulin.
• 10. Self-report a history or current diagnosis of schizophrenia or bipolar disorder unless cleared by study physician.
• 11. Self-report of a history or current diagnosis of post-traumatic stress disorder or eating disorder unless cleared by study physician.
• 12. Current Substance Use Disorder (DAST score \>3 or use \>0 in the past year and refuses to refrain from use for the duration of the study; USAUDIT score \>15)
• 13. Individuals who report depressive symptoms in the moderately severe or severe range on the PHQ-9 (scores of 15 or above); or who report current suicidal ideation on the PHQ-9
• 14. Individuals who report anxiety symptoms in the severe range on the GAD-7 (scores of 15 or above); or meet criteria for Panic Syndrome on the PHQ Panic module.
• 15. Psychiatric hospitalization or suicidal ideation within 1 year of screening date
• 16. Currently receiving treatment for substance abuse (e.g., alcohol, opioids, cocaine, marijuana, or stimulants).
• 17. Use of marijuana or other illicit drugs in the last 3 months.
• 18. Current or recent use (last 3 months) of smoking cessation medication (e.g., Zyban, Wellbutrin, Wellbutrin SR, Chantix) or nicotine replacement therapy.
• 19. Have undergone bariatric surgery.
• 20. Currently being enrolled in a weight loss program
• 21. Takes any prescription or over the counter medications or supplements to control weight and/or appetite.
• 22. Severe insomnia (\<4 hours sleep per night with hypnotic)
• 23. Sleep Deprived (\<4 hours of sleep) the day of the visit
• 24. Current use of certain medications (last 3 months):
• * Investigational drugs.
• * Drugs of anti or pro-convulsive action. Medications with psychotropic effects (e.g., antidepressants, antipsychotics).
• 25. Medications known to increase risk of seizure taken within 1 week of enrollment
• 26. Being pregnant or lactating (as determined by participant self-report).
• 27. Reported allergies to chocolate or any ingredient in the M\&M candies.
• 28. Noise-induced hearing loss or tinnitus.
• 29. Reported history of vision problems that are not treated.
• 30. Has a hairstyle not compatible with the EEG and unwilling to modify hairstyle (e.g., braids, ponytails, dreadlocks, non-removable hair extensions or wigs, etc.) to accommodate the EGG net that is required to be worn on the scalp during the experimental procedure
• 31. Any otherwise not specified medical or psychiatric condition, illness, disorder, or concomitant medication that could compromise participant safety or treatment, as determined by the Principal Investigator and/or Study Physician
• 32. Subjects considered by the investigator as unsuitable for the study for reasons not otherwise stated.