RECRUITING

PKP2-ACM Natural History Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to describe the natural history and clinical events for patients who have Arrhythmogenic Cardiomyopathy with Pathogenic Plakophilin-2 Variants (PKP2-ACM) managed with standard of care.

Official Title

The Natural History of Arrhythmogenic Cardiomyopathy With Pathogenic Plakophilin-2 Variants (PKP2-ACM): An Observational Cohort Study

Quick Facts

Study Start:2025-09
Study Completion:2028-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06644742

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:12 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Clinical Information
CONTACT
646-627-0033
clinicaltrials@rocketpharma.com

Study Locations (Sites)

Boston Children's Hospital
Boston, Massachusetts, 02116
United States
Duke University
Durham, North Carolina, 27710
United States

Collaborators and Investigators

Sponsor: Rocket Pharmaceuticals Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09
Study Completion Date2028-12

Study Record Updates

Study Start Date2025-09
Study Completion Date2028-12

Terms related to this study

Keywords Provided by Researchers

  • Arrhythmogenic Cardiomyopathy
  • Plakophilin-2
  • Arrhythmogenic Cardiomyopathy (AC, ARVD/C)
  • PKP2

Additional Relevant MeSH Terms

  • Cardiomyopathies
  • Heart Diseases
  • Cardiovascular Diseases
  • Genetic Diseases