RECRUITING

Exosome-based Detection of Molecular Residual Disease in Stage II-III Colorectal Cancer.

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to establish an exosome-based liquid biopsy signature to detect molecular residual disease (MRD) in stage II-III colorectal cancer (CRC) patients. Identifying patients with MRD after surgery is crucial for selecting appropriate candidates for adjuvant chemotherapy (ACT), allowing for more personalized treatment approaches and potentially improving patient outcomes.

Official Title

An Exosome-Based Liquid Biopsy Assay to Detect Molecular Residual Disease for the Identification of High-Risk Patients with Stage II-III Colorectal Cancer

Quick Facts

Study Start:2023-04-01
Study Completion:2024-12-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06654622

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Patients with pathologically confirmed stage II or III colorectal cancer.
  2. 2. Patients who have undergone curative-intent surgery.
  3. 3. Patients with no evidence of distant metastasis (stage IV).
  4. 4. Patients aged 18 years or older.
  5. 5. Patients who provided written informed consent.
  1. 1. Patients with stage IV cancer or those receiving neoadjuvant therapy.
  2. 2. Patients with non-curative resection or requiring urgent surgery.
  3. 3. Patients with a follow-up period of fewer than 3 years.
  4. 4. Patients with severe comorbidities or who are unable to participate in follow-up assessments.

Contacts and Locations

Study Contact

Takayuki Noma, MD
CONTACT
6268418625
tnoma@coh.org

Principal Investigator

Ajay Goel, PhD
PRINCIPAL_INVESTIGATOR
City of Hope Medical Center

Study Locations (Sites)

City of Hope Medical Center
Duarte, California, 91010
United States

Collaborators and Investigators

Sponsor: City of Hope Medical Center

  • Ajay Goel, PhD, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-04-01
Study Completion Date2024-12-30

Study Record Updates

Study Start Date2023-04-01
Study Completion Date2024-12-30

Terms related to this study

Keywords Provided by Researchers

  • Colorectal cancer
  • Molecular residual disease
  • Adjuvant chemotherapy
  • Stage II-III CRC
  • exosomal miRNA

Additional Relevant MeSH Terms

  • Colo-rectal Cancer
  • Colorectal Cancer Recurrent