RECRUITING

Family Members At INcreased-risk for Developing Inflammatory Bowel Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

First-degree relatives of people with inflammatory bowel disease ("IBD," including Crohn's disease and ulcerative colitis) have an increased risk for developing IBD themselves. This study will follow unaffected first-degree relatives (who do not have IBD) over time to understand if their behaviors, diet, and biomarkers for IBD can help predict who gets IBD and if IBD can be prevented in these high-risk individuals. Participants will be asked once per year to complete a questionnaire and have their blood, stool, and urine collected. The anticipated length of the study (registry) is approximately 10 years or longer. Parts of this study, such as the questionnaires and stool and urine collection, may be done from home, while other parts, such as the blood draw, will need to be done from Massachusetts General Hospital.

Official Title

Family Members At INcreased-risk for Developing Inflammatory Bowel Disease (FIND-IBD)

Quick Facts

Study Start:2024-12-18
Study Completion:2034-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06655415

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:14 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Ability to give informed consent
  2. * Ability to complete all study visits and study-related procedures
  3. * Ability to understand and complete study questionnaires
  4. * Must have at least one first-degree relative with inflammatory bowel disease (Crohn's disease, ulcerative colitis, or IBD-unclassified)
  5. * Age ≥ 14
  1. * Individuals with existing diagnoses of inflammatory bowel disease (ulcerative colitis, Crohn's disease, or IBD-unclassified)
  2. * Evidence of clinical signs or symptoms of IBD, which will be identified on pre-screening interview with the study coordinator.

Contacts and Locations

Study Contact

Emily W Lopes, MD, MPH
CONTACT
617-726-5560
mghfindibd@mgb.org

Principal Investigator

Emily W Lopes, MD, MPH
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02114
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Emily W Lopes, MD, MPH, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12-18
Study Completion Date2034-12

Study Record Updates

Study Start Date2024-12-18
Study Completion Date2034-12

Terms related to this study

Keywords Provided by Researchers

  • Inflammatory Bowel Disease
  • IBD
  • Ulcerative colitis
  • Crohn's disease

Additional Relevant MeSH Terms

  • Inflammatory Bowel Disease (IBD)
  • Ulcerative Colitis (UC)
  • IBD-unclassified (IBD-U)
  • Indeterminate Colitis
  • Crohn's Disease Colon
  • Crohn's Colitis
  • Crohn's Ileocolitis
  • Crohn's Gastritis
  • Crohn's Jejunitis
  • Crohn's Duodenitis
  • Crohn's Esophagitis
  • Ulcerative Proctitis
  • Ulcerative Proctosigmoiditis