Phase 2 Seattle Dietary Biomarkers Development Center

Eligibility Criteria

• * Healthy adults;
• * Age 18 years or older;
• * Willing to come to the Fred Hutch campus 10 times during the study; BMI 18.5-39.9 kg/m2
• * Pregnancy or lactation;
• * allergy or aversion to any of the foods that will be studied and/or provided;
• * history of gastrointestinal disorders including ulcerative colitis, Crohn's disease, celiac sprue, hereditary non-polyposis colorectal cancer (HNPCC), familial adenomatous polyposis, pancreatic disease, or liver disease;
• * previous gastrointestinal resection or bariatric surgery;
• * bleeding disorders that precludes blood draws;
• * recent hospital admissions (past 6 months) for heart disease (MI/CVA or CHF) or other CVD/CAD conditions under physician guided therapy that is not medically stable;
• * cancer under radiation or chemotherapy treatment that is active or within 6 months of treatment;
• * weight change (±5% in the last 3 months);
• * regular alcohol intake of \> 2 drinks/day (equivalent to 720 mL of beer, 240 mL of wine, or 90 mL of spirits), and unwilling to abstain during feeding periods;
• * use of tobacco and/or marijuana, hookahs, e-cigarettes (e-cigs, vapes, etc) and not willing to abstain during feeding periods;
• * use of illicit drugs and not willing to abstain during feeding periods;
• * BMI ≥40 kg/m2; regular (daily to weekly) use of over-the-counter (OTC) weight-loss aids or anti-inflammatories, and unwilling or unable to stop taking these during feeding periods;
• * unwilling to stop taking OTC dietary supplements that interfere with the test foods being studied including pills, chewables, liquids or powders for the following: protein supplements, soy, fiber, flaxseed, fish oil (including cod liver oil), probiotics, carotenoids, selenium, other antioxidants, other phytochemicals, glucosamine and chondroitin (if vitamin supplement is MD prescribed - may continue);
• * oral or IV antibiotic use in the past 6 months (could defer participation until 6 months post-completion of course of antibiotics);
• * seated blood pressure \>140/90 mmHg; fasting clinical lab tests outside acceptable values as ascertained at the screening blood draw (see Table 2 in protocol document);
• * current use of specific prescription medication(s) (see Table 3 in protocol document); and
• * inability to freely give informed consent.