RECRUITING

Phase 1 Study of ACR-2316 in Specific Advanced Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a first in-human, Open-label Phase 1 study to assess the safety of ACR-2316 for the treatment of subjects with specific, histologically confirmed, locally advanced, recurrent or metastatic solid tumors.

Official Title

ACR-2316-101: Phase 1 Study of ACR-2316 in Subjects With Advanced Solid Tumors

Quick Facts

Study Start:2024-10-08
Study Completion:2026-12-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06667141

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Signed written informed consent.
  2. 2. Histologically or cytologically proven metastatic, recurrent or locally advanced selected solid tumors.
  3. 3. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1 at trial entry and an estimated life expectancy of at least 3 months.
  4. 4. Disease must be measurable with at least 1 unidimensional measurable lesion by RECIST v1.1.
  5. 5. Adequate organ functions.
  6. 6. Must have progressed after prior line of treatment.
  7. 1. Participants with known symptomatic brain metastases.
  8. 2. Participant had systemic therapy or radiation therapy within 2 weeks prior to the first dose of study drug.
  9. 3. Women who are pregnant or lactating.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jean-Marie Cuillerot, MD
CONTACT
617-207-8976
ACR-2316ClinicalTrial@acrivon.com
Monica Phadnis
CONTACT
ACR-2316ClinicalTrial@acrivon.com

Study Locations (Sites)

Carolina BioOncology Institute
Huntersville, North Carolina, 28078
United States
The University of Texas MD Anderson Cancer Center
Houston, Texas, 77054
United States
NEXT Oncology
San Antonio, Texas, 78229
United States
Next Virginia
Fairfax, Virginia, 22031
United States

Collaborators and Investigators

Sponsor: Acrivon Therapeutics

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-08
Study Completion Date2026-12-12

Study Record Updates

Study Start Date2024-10-08
Study Completion Date2026-12-12

Terms related to this study

Keywords Provided by Researchers

  • ACR-2316
  • WEE1
  • PKMYT1
  • Locally advanced, recurrent or metastatic solid tumors

Additional Relevant MeSH Terms

  • Specific Advanced Solid Tumors