RECRUITING

Effect of Force Magnitude on Canine Retraction and Gingival Crevicular Fluid Proteome

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to examine the effect of force levels in orthodontic treatment during canine retraction. Force levels refer to the pressure applied by the orthodontic devices to move teeth. Data collection will include gingival fluid, dental molds from a digital scanner, and x-rays of the upper canine region on both sides of the mouth during treatment. The null hypothesis to be tested is that there is no significant difference in the rate of canine movement between the light force and the heavy force levels.

Official Title

A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile

Quick Facts

Study Start:2024-11-13
Study Completion:2028-04-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06668194

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:11 Years to 16 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Healthy patient, non-smoker
  2. * Age: 11 - 16 years of age, inclusive.
  3. * A full complement of dentition (central incisor to 1st molar) in the four quadrants, except second molars
  4. * Patients requiring at least upper bilaterally maxillary 1st premolar extraction as a treatment plan (Class I bimaxillary protrusion/ crowding or Class II maxillary dentoalveolar protrusion/ crowding)
  5. * At least 5 mm of space left between canine and 2nd premolar to be closed at the time of canine retraction
  6. * At least six months after the extraction of first premolars and in a 0.019 x 0.025-inch stainless steel archwire in the maxilla
  7. * The ability to read and understand English and to provide informed consent
  1. * Patients under 11 years of age and over the age of 16.
  2. * Non-extraction treatment plan
  3. * Extraction of maxillary tooth other than first premolars bilaterally.
  4. * Evidence of poor oral hygiene
  5. * Evidence of previous root resorption
  6. * Missing or impacted tooth in any of the quadrant except 3rd molars.
  7. * Medical issues that affect tooth movement
  8. * Inability to provide oral and written consent to participate.
  9. * Patient on medications that may alter bone metabolisms like bisphosphonates, oral contraceptives, or PTH (parathyroid hormone)
  10. * Chronic illness or syndromic patients.
  11. * Pregnant women, prisoners, and decisional impaired

Contacts and Locations

Study Contact

Flavio Uribe, DDS, MDentSc
CONTACT
860-679-2664
furibe@uchc.edu
Georgiana Defilio
CONTACT
860-679-2550

Principal Investigator

Flavio Uribe, DDS, MDentSc
PRINCIPAL_INVESTIGATOR
UConn Health

Study Locations (Sites)

Department of Orthodontics
Farmington, Connecticut, 06032
United States

Collaborators and Investigators

Sponsor: UConn Health

  • Flavio Uribe, DDS, MDentSc, PRINCIPAL_INVESTIGATOR, UConn Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-13
Study Completion Date2028-04-01

Study Record Updates

Study Start Date2024-11-13
Study Completion Date2028-04-01

Terms related to this study

Keywords Provided by Researchers

  • Orthodontic space closure
  • Canine retraction
  • Gingival crevicular fluid
  • Proteomics

Additional Relevant MeSH Terms

  • Tooth Crowding