Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients

Description

Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a measure of skeletal muscle health. Participants will ride a stationary bicycle and the quadriceps muscle will be non-invasively evaluated.

Conditions

Breast Cancer, Gynecologic Cancers, Mitochondrial Function

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Study Overview

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Study Details

Study overview

Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a measure of skeletal muscle health. Participants will ride a stationary bicycle and the quadriceps muscle will be non-invasively evaluated.

Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients

Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Greenville

Prisma Health Cancer Institute, Greenville, South Carolina, United States, 29605

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients diagnosed with breast cancer or gynecological cancer without distance metastasis
  • * Able to perform exercise on a stationary cycle ergometer at moderate intensities for a maximum of 15 minutes
  • * Hemoglobin values greater than 10 at baseline
  • * ALT and AST values less than 2.5X the upper limit of normal by institutional standards
  • * Godin-Shepard Leisure time Physical Activity Questionnaire (GLTEQ) score of 14 or greater will be included. A score of less than 14 is considered insufficiency active/sedentary
  • * Metastatic breast or gynecological cancer
  • * Clinically advanced cardiovascular disease
  • * Clinically advanced pulmonary disease
  • * Disease requiring continuous oxygen supplementation
  • * Greater than 2 centimeters or more of subcutaneous adipose tissue on the anterior thigh
  • * Inability to walk or stand
  • * Movement disorders
  • * Spinal cord injuries
  • * Autoimmune disorders
  • * Pregnant or breastfeeding
  • * Mini-Mental State Examination (MMSE) \<24

Ages Eligible for Study

20 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of South Carolina,

Jennifer L Trilk, PhD, PRINCIPAL_INVESTIGATOR, University of South Carolina School of Medicine, Greenville

Randolph Hutchison, PhD, PRINCIPAL_INVESTIGATOR, Furman University

Larry Gluck, MD, PRINCIPAL_INVESTIGATOR, Prisma Health

Study Record Dates

2026-03