Neonatal Platelet Transfusion Threshold Trial

Description

The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).

Conditions

Thrombocytopenia, Neonatal, Platelet Transfusion, Infant, Newborn, Diseases, Infant, Extremely Low Birth Weight, Infant, Small for Gestational Age, Thrombosis

Study Overview

Study Details

Study overview

The objective of the NeoPlaTT trial is to test whether, among extremely preterm infants born at 23 0/7 to 26 6/7 weeks' gestation, a lower platelet transfusion threshold, compared to a higher threshold, improves survival without major or severe bleeding up to 40 0/7 weeks' postmenstrual age (PMA).

Neonatal Platelet Transfusion Threshold Trial

Neonatal Platelet Transfusion Threshold Trial

Condition
Thrombocytopenia
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35233

Palo Alto

Stanford University, Palo Alto, California, United States, 94304

San Diego

Sharp Mary Birch Hospital for Women & Newborns, San Diego, California, United States, 92123

Aurora

University of Colorado, Aurora, Colorado, United States, 80045

Atlanta

Emory University, Atlanta, Georgia, United States, 30303

Chicago

Northwestern Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60611

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Albuquerque

University of New Mexico, Albuquerque, New Mexico, United States, 87131

Rochester

University of Rochester, Rochester, New York, United States, 14642

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Gestational age of 23 0/7 to 26 6/7 weeks
  • * Postnatal age of \< 48 hours
  • * Comfort care or withdrawal of care planned
  • * Neonatal alloimmune thrombocytopenia or suspected/confirmed congenital platelet or bleeding disorder
  • * Receipt of platelet transfusion
  • * No receipt of Vitamin K
  • * Parents/guardian decline consent

Ages Eligible for Study

1 Hour to 48 Hours

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

NICHD Neonatal Research Network,

Ravi M Patel, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2031-04-30