RECRUITING

E-cigarette Cessation in Adults Who Co-use Cannabis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.

Official Title

A Prospective Trial of Varenicline and Incentives for E-cigarette Cessation in Adults Who Co-use Cannabis

Quick Facts

Study Start:2025-02-19
Study Completion:2026-10-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06688539

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Between the ages of 18 and 40 years old
  2. * Use e-cigarettes daily or near daily in the past month
  3. * Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
  4. * Be interested in quitting use of e-cigarettes
  5. * Must be willing to take varenicline for the standard 12-week course of treatment
  6. * Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)
  1. * Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
  2. * Use of cigarettes on 10+ days in the past 30
  3. * Currently pregnant or breastfeeding
  4. * Current use of medications with smoking cessation efficacy
  5. * Use of any medications that would interfere with varenicline

Contacts and Locations

Study Contact

Elizabeth Chapman, MA, LPC, LAC, AADC
CONTACT
864.898.2992
chapmanb@musc.edu

Principal Investigator

Erin A McClure, PhD
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

MUSC Charleston
Charleston, South Carolina, 29425
United States
MUSC Lancaster
Lancaster, South Carolina, 29720
United States
Behavioral Health Services of Pickens County
Pickens, South Carolina, 29671
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Erin A McClure, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-19
Study Completion Date2026-10-01

Study Record Updates

Study Start Date2025-02-19
Study Completion Date2026-10-01

Terms related to this study

Keywords Provided by Researchers

  • e-cigarettes
  • cannabis
  • treatment

Additional Relevant MeSH Terms

  • Nicotine Dependence
  • Tobacco Use Disorder