E-cigarette Cessation in Adults Who Co-use Cannabis

Description

The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.

Conditions

Nicotine Dependence, Tobacco Use Disorder

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Study Overview

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Study Details

Study overview

The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.

A Prospective Trial of Varenicline and Incentives for E-cigarette Cessation in Adults Who Co-use Cannabis

E-cigarette Cessation in Adults Who Co-use Cannabis

Condition
Nicotine Dependence
Intervention / Treatment

-

Contacts and Locations

Charleston

MUSC Charleston, Charleston, South Carolina, United States, 29425

Lancaster

MUSC Lancaster, Lancaster, South Carolina, United States, 29720

Pickens

Behavioral Health Services of Pickens County, Pickens, South Carolina, United States, 29671

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Between the ages of 18 and 40 years old
  • * Use e-cigarettes daily or near daily in the past month
  • * Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
  • * Be interested in quitting use of e-cigarettes
  • * Must be willing to take varenicline for the standard 12-week course of treatment
  • * Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)
  • * Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
  • * Use of cigarettes on 10+ days in the past 30
  • * Currently pregnant or breastfeeding
  • * Current use of medications with smoking cessation efficacy
  • * Use of any medications that would interfere with varenicline

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Medical University of South Carolina,

Erin A McClure, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

2026-10-01