RECRUITING

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

Conditions

Aging Sarcopenia Sarcopenia in Elderly Motoneuronal Activation Electrical Stimulation Whole-Body Stimulation Exercise Intervention Exercise

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

During this pilot study, the investigators will examine the effects of whole-body electrical muscle stimulation exercise (WB-EMS Exercise) on motoneuronal activation in healthy adults, which typically decreases with age. The investigators will also test whether WB-EMS Exercise will improve measures of physical function. Participants will undergo clinical and electrophysiologic testing before and after the WB-EMS Exercise intervention. The WB-EMS Exercise intervention will be delivered two times per week for four weeks. The hypothesis is that whole-body electrical muscle stimulation combined with physical exercise (WB-EMS Exercise) could bypass the problem of insufficient motoneuronal activation to improve exercise effect in older adults.

Official Title

Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults

Quick Facts

Study Start:2025-06-01

Study Completion:2025-12

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06689618

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age (65 years or older) for healthy older adults and between 18-39 for healthy younger adults * Ambulatory without an assistive device * More than anti-gravity strength in major muscle groups as assessed by manual muscle testing * Medical clearance to participate in an exercise program * Ability to conform to the requirements of the study (i.e. attendance at assessment and intervention visits, maintain current level of non-study physical activity for the duration of the study, no intention to relocate mid-study)	* Regular use of an assistive device for mobility (i.e. cane, walker, wheelchair) * Presence of a pacemaker, metal implants, or other implanted medical devices that could impact participant safety during WB-EMS intervention * Known pregnancy at the time of screening * Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease cardia arrhythmia, neoplasm, uncontrolled hypertension) * Presence of terminal disease (i.e. receiving hospice services) * Current of previous use of any drugs known to influence muscle mass or performance within 6 months; these may include but are not limited to anabolic steroids, IGF01, growth hormone, replacement and androgen therapy, anti-androgen therapy. * Known neuromuscular or neurologic condition affecting somatosensory or motor function/control (i.e. motor neuron disease, muscle disease, severe peripheral neuropathy, NMJ disease, Parkinson's disease, Multiple Sclerosis, h/o stroke, TBI, SCI, ataxia, apraxia, hemiplegia, etc.) * Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. TKA, THA, RTC repair, spinal fusion) * Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by a PI

Inclusion Criteria

Exclusion Criteria

* Age (65 years or older) for healthy older adults and between 18-39 for healthy younger adults
* Ambulatory without an assistive device
* More than anti-gravity strength in major muscle groups as assessed by manual muscle testing
* Medical clearance to participate in an exercise program
* Ability to conform to the requirements of the study (i.e. attendance at assessment and intervention visits, maintain current level of non-study physical activity for the duration of the study, no intention to relocate mid-study)

* Regular use of an assistive device for mobility (i.e. cane, walker, wheelchair)
* Presence of a pacemaker, metal implants, or other implanted medical devices that could impact participant safety during WB-EMS intervention
* Known pregnancy at the time of screening
* Presence of unstable acute or chronic disease (i.e. renal failure, rheumatologic disease cardia arrhythmia, neoplasm, uncontrolled hypertension)
* Presence of terminal disease (i.e. receiving hospice services)
* Current of previous use of any drugs known to influence muscle mass or performance within 6 months; these may include but are not limited to anabolic steroids, IGF01, growth hormone, replacement and androgen therapy, anti-androgen therapy.
* Known neuromuscular or neurologic condition affecting somatosensory or motor function/control (i.e. motor neuron disease, muscle disease, severe peripheral neuropathy, NMJ disease, Parkinson's disease, Multiple Sclerosis, h/o stroke, TBI, SCI, ataxia, apraxia, hemiplegia, etc.)
* Musculoskeletal condition or surgery in the past year that would confound results of exercise interventions (i.e. TKA, THA, RTC repair, spinal fusion)
* Other medical conditions, signs, or symptoms that would interfere with study conduct or interpretation of results as determined by a PI

Contacts and Locations

Study Contact

Kristina Kelly, DPT, MS

CONTACT

5738842596

kristina.kelly@health.missouri.edu

W. David Arnold, MD

CONTACT

Study Locations (Sites)

NextGen Precision Health Building, Clinical and Translational Science Unit

Columbia, Missouri, 65211

United States

Collaborators and Investigators

Sponsor: University of Missouri-Columbia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-01

Study Completion Date2025-12

Study Record Updates

Study Start Date2025-06-01

Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

Aging
Motoneuronal Activation
Electrical Stimulation
Whole-Body Stimulation
Sarcopenia
Exercise Intervention
Exercise

Additional Relevant MeSH Terms

Aging
Sarcopenia
Sarcopenia in Elderly