At-the-Breast Vs. Expressed Human Milk: Genesis of Infant Nutrition (BEGIN)

Description

The purpose of this study is to define human milk (HM) as an ecosystem which investigators will then combine into temporal models of milk dynamics to accurately describe HM chronobiology. This study addresses 4 crucial public health gaps: 1) how breast milk changes over time and over the day, 2) how milk dynamics are related to infant sleep patterns, 3) how milk dynamics are related to infant microbiome dynamics, and 4) how all these relationships differ between infants fed directly at-the-breast vs pumped milk. These fundamental insights have been unknown until now, so that families who feed pumped breast milk are completely underserved. These results are critical to optimizing infant feeding and health outcomes for all infants receiving breast milk.

Conditions

Breast Feeding, Exclusive Breastfeeding

Study Overview

Study Details

Study overview

The purpose of this study is to define human milk (HM) as an ecosystem which investigators will then combine into temporal models of milk dynamics to accurately describe HM chronobiology. This study addresses 4 crucial public health gaps: 1) how breast milk changes over time and over the day, 2) how milk dynamics are related to infant sleep patterns, 3) how milk dynamics are related to infant microbiome dynamics, and 4) how all these relationships differ between infants fed directly at-the-breast vs pumped milk. These fundamental insights have been unknown until now, so that families who feed pumped breast milk are completely underserved. These results are critical to optimizing infant feeding and health outcomes for all infants receiving breast milk.

At-the-Breast Vs. Expressed Human Milk: Genesis of Infant Nutrition (BEGIN)

At-the-Breast Vs. Expressed Human Milk: Genesis of Infant Nutrition (BEGIN)

Condition
Breast Feeding
Intervention / Treatment

-

Contacts and Locations

Rochester

University of Rochester Medical Center, Rochester, New York, United States, 14642

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Lactating mothers between 20-40 years old at enrollment
  • * pumping no more than one time per day)
  • * All races and ethnicities may enroll
  • * Singleton infant delivered after 37 weeks
  • * Infant between the ages of 0-1 months at the time of enrollment.
  • * No serious health complications in mother or infant
  • * Non-English-speaking subjects as study personnel only speak English
  • * Lactating moms who will be feeding both ATB and expressed HM (over 25% of the time in either feeding mode)
  • * Infant supplementation with formula ≥10 oz before sample collections begin, and/or no more than 16 oz during active participation/ sample collections.

Ages Eligible for Study

0 Days to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Rochester,

Study Record Dates

2029-11-01