RECRUITING

Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach

Conditions

Interaction pharmacokinetics drug interaction natural products oregano cytochrome P450 cocktail

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this clinical trial is to determine how the supplement oregano affects how the body metabolizes pharmaceutical drugs.

Official Title

Evaluating the Pharmacokinetics of Oregano and Potential Oregano-drug Interactions Using a Drug Cocktail Approach

Quick Facts

Study Start:2024-09-26

Study Completion:2025-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06693960

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 64 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Between 18-64 years old and healthy * Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics * Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks * Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks * Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm * Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day * Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the use hormonal-based birth control, a non-hormonal method should be used for the duration of the study and for three weeks following cessation of participation. * Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study * Geographically located within a 40-mile radius of Spokane and have the time to participate	* Under 18 or over 64 years old * Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics * Have a major illness * Taking medication/supplements for a mineral deficiency * History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole) * Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month * Currently using drugs or illicit substances for recreational purposes * Pregnant or nursing * Geographically located outside the 40-mile radius of Spokane and do not have the time to participate * Cannot read and speak English

Inclusion Criteria

Exclusion Criteria

* Between 18-64 years old and healthy
* Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics
* Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks
* Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks
* Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm
* Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day
* Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the use hormonal-based birth control, a non-hormonal method should be used for the duration of the study and for three weeks following cessation of participation.
* Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study
* Geographically located within a 40-mile radius of Spokane and have the time to participate

* Under 18 or over 64 years old
* Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics
* Have a major illness
* Taking medication/supplements for a mineral deficiency
* History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)
* Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month
* Currently using drugs or illicit substances for recreational purposes
* Pregnant or nursing
* Geographically located outside the 40-mile radius of Spokane and do not have the time to participate
* Cannot read and speak English

Contacts and Locations

Study Contact

Mary F Paine, RPh, PhD

CONTACT

509-358-7759

mary.paine@wsu.edu

Study Locations (Sites)

Washington State University College of Pharmacy and Pharmaceutical Sciences

Spokane, Washington, 99202

United States

Collaborators and Investigators

Sponsor: Washington State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-26

Study Completion Date2025-12-31

Study Record Updates

Study Start Date2024-09-26

Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

pharmacokinetics
drug interaction
natural products
oregano
cytochrome P450
cocktail

Additional Relevant MeSH Terms

Interaction