RECRUITING

Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Our primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent smokers. Our secondary objective will be to measure the protocols' effectiveness to increase decision-making capacity using the probabilistic selection task (PST). Our third objective will be to specifically assess whether the TMS targets has a differential impact on state levels of craving relative to baseline (Tobacco Craving Questionnaire \[TCQ\]. We plan to accomplish these three objectives using a randomized, controlled experiment involving 2 sessions.

Official Title

Determining the Optimal Pulse Protocol for TMS Induced Change in Reward Positivity

Quick Facts

Study Start:2024-08-01
Study Completion:2025-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06695884

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Nicotine dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test nicotine dependence score).
  2. 2. Be between the ages of 18 and 55 years old.
  3. 3. Not received substance abuse treatment within the previous 30 days.
  4. 4. Be in stable mental and physical health.
  5. 5. If female, test non-pregnant.
  6. 6. No evidence of focal or diffuse brain lesion on MRI.
  7. 7. Be willing to provide informed consent.
  8. 8. Be able to comply with protocol requirements and likely to complete all study procedures.
  1. 1. Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia).
  2. 2. Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \> 15 minutes, implanted electronic device, metal in the head, or pregnancy).
  3. 3. History of autoimmune, endocrine, viral, or vascular disorder affecting the brain.
  4. 4. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment.
  5. 5. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression.
  6. 6. uninterruptable central nervous system medication

Contacts and Locations

Study Contact

Travis E Baker, PhD
CONTACT
973-353-5485
travis.e.baker@rutgers.edu
Emily Zhang
CONTACT
973-353-3509
travis.e.baker@rutgers.edu

Principal Investigator

Travis E Baker, PhD
PRINCIPAL_INVESTIGATOR
Rutgers University

Study Locations (Sites)

Rutgers University - Newark
Newark, New Jersey, 07102
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Travis E Baker, PhD, PRINCIPAL_INVESTIGATOR, Rutgers University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-01
Study Completion Date2025-08-31

Study Record Updates

Study Start Date2024-08-01
Study Completion Date2025-08-31

Terms related to this study

Keywords Provided by Researchers

  • transcranial magnetic stimulation
  • reward processing
  • EEG
  • smoking

Additional Relevant MeSH Terms

  • Nicotine Use Disorder