Resistance Training for the Improvement of Glycemic Control in Prediabetes

Eligibility Criteria

• * age between 18 and 75 years;
• * presence of prediabetes (fasting glycemia between 100 and 125 mg/dL or glycated hemoglobin \[A1c\] between 5.7 and 6.4%).
• * Have a significant cognitive impairment,
• * Are non-ambulatory,
• * Have lower extremity amputation,
• * Have renal failure,
• * Have liver disease,
• * Have uncontrolled hypertension (\>160 mmHg systolic and/or \>100 mmHg diastolic),
• * Have unstable cardiovascular disease,
• * Have a history of severe cardiovascular problems,
• * Have decompensated heart failure,
• * Have uncontrolled arrhythmias,
• * Have severe pulmonary hypertension (mean pulmonary arterial pressure \>55 mm Hg),
• * Have severe and symptomatic aortic stenosis,
• * Have acute myocarditis, endocarditis, or pericarditis,
• * Have aortic dissection,
• * Have Marfan syndrome,
• * Have unrepaired aortic aneurysm,
• * Have proliferative diabetic retinopathy,
• * Have rapidly progressive terminal illness,
• * Are unable to perform resistance exercise to due preexisting musculoskeletal conditions (e.g., joint pain, chronic injury or tendinopathy),
• * Are under biguanide (metformin) treatment, but are taking for less than 3 months,
• * Have taken drugs known to increase the risk of tendon disorders (e.g., tendinopathy and tendon rupture) within the last 6 months. These drugs include, but may not be limited to: fluoroquinolones, glucocorticoids, aromatase inhibitors, anabolic steroids, antiretrovirals, isotretinoin, cephalexin, rituximab, sitagliptin, cephalosporins, azithromycin, and sulfonamides.
• * Are pregnant or trying to become pregnant during the study,
• * Are prisoners,
• * Are persons that require a legally authorized representative.
• * Being subjected to recent surgeries for which resistance training is not recommended,
• * Have symptomatic hernias,
• * Have acute illness,
• * Have recent fractures, or other injuries until resolved.