RECRUITING

Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to evaluate a long Clomid protocol as compared to a 5-day Clomid protocol for ovarian stimulation in patients with diminished ovarian reserve undergoing ovarian stimulation for in-vitro fertilization. The aim of the long Clomid protocol is to intensify stimulation of the ovaries and reduce both cost and injection burden for patients. Participants will be randomized to receive the long Clomid protocol vs. the typical protocol involving Clomid only for 5 days followed by growth hormone-releasing hormone (GnRH) antagonist. The primary outcome the investigators will evaluate will be the number of mature eggs retrieved.

Official Title

Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation in Patients With Diminished Ovarian Reserve Undergoing In-vitro Fertilization: a Randomized Controlled Trial

Quick Facts

Study Start:2025-06-01
Study Completion:2027-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06701071

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Undergoing IVF
  2. * Must meet POSEIDON criteria based on clinic evaluation
  3. * Female partner: Antral follicle count of 2 or more and age \<45 at time of stimulation start
  4. * Male partner/sperm source: Cannot be azoospermic
  5. * Planning freeze-all cycle (regardless of blastocyst or cleavage stage culture) or fresh transfer if randomized to short Clomid group
  6. * Planning 36-hour trigger window
  1. * Normal ovarian reserve or good response
  2. * Allergy or adverse reaction to Clomid
  3. * Minimal stimulation protocols
  4. * History of prior premature ovulation

Contacts and Locations

Study Contact

Richard Paulson
CONTACT
323-409-3026
paulsonivf@havingbabies.com
Rachel Mandelbaum
CONTACT
323-409-3026
mandelbaumivf@havingbabies.com

Principal Investigator

Richard Paulson
PRINCIPAL_INVESTIGATOR
paulsonivf@havingbabies.com

Study Locations (Sites)

HRC Fertility
Pasadena, California, 91101
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Richard Paulson, PRINCIPAL_INVESTIGATOR, paulsonivf@havingbabies.com

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-01
Study Completion Date2027-12

Study Record Updates

Study Start Date2025-06-01
Study Completion Date2027-12

Terms related to this study

Additional Relevant MeSH Terms

  • Infertility, Female