Nitrous Oxide Neuroimaging

Description

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Conditions

Anesthesia, Pain, Amnesia

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Functional MRI of Nitrous Oxide Inhalation in Volunteer Subjects

Nitrous Oxide Neuroimaging

Condition
Anesthesia
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * have none of the specific exclusion criteria
  • * have a valid email address and valid phone number throughout the study
  • * free from any non-MRI compatible implants
  • * are pregnant or attempting to conceive
  • * body mass index (BMI) \> 35
  • * significant memory impairment or hearing loss
  • * sleep apnea
  • * chronic pain or frequently taking pain medication (including tramadol)
  • * any severe or poorly-controlled medical problem (hypertension, diabetes)
  • * neurologic or psychiatric disease, including anxiety, and depression
  • * severe cardiac disease
  • * history of methylenetetrahydrofolate reductase (MTHFR) deficiency or variant mutation, as assessed by personal report
  • * recent ear or eye surgery
  • * being claustrophobic
  • * have metal implants or non-removable metal piercings
  • * having a history of adverse reaction to anesthetics
  • * daily alcohol or heavy alcohol use; history of alcohol abuse
  • * current daily smoker
  • * regular or recent marijuana use (including prescribed/medical marijuana)
  • * illicit drug use, i.e., street drugs
  • * regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids

Ages Eligible for Study

18 Years to 59 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Keith M Vogt,

Study Record Dates

2026-01-01