Guerbet Liver Fibrosis

Description

The goal of this study is to assess the value of liver dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and texture analysis post gadopiclenol for liver fibrosis staging, in comparison with MR elastography, T1 mapping, ultrasound elastography and blood tests in 50 initial patients with metabolic dysfunction-associated steatohepatitis (MASH).

Conditions

Metabolic Dysfunction-associated Steatotic Liver Disease

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Study Overview

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Study Details

Study overview

The goal of this study is to assess the value of liver dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and texture analysis post gadopiclenol for liver fibrosis staging, in comparison with MR elastography, T1 mapping, ultrasound elastography and blood tests in 50 initial patients with metabolic dysfunction-associated steatohepatitis (MASH).

Noninvasive Diagnosis of Liver Fibrosis With Gadopiclenol DCE-MRI in Metabolic Dysfunction-associated Steatohepatitis (MASH)

Guerbet Liver Fibrosis

Condition
Metabolic Dysfunction-associated Steatotic Liver Disease
Intervention / Treatment

-

Contacts and Locations

New York

Mount Sinai, New York, New York, United States, 10029

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with suspected MASLD (F0-F4) with clinically indicated percutaneous or transjugular liver biopsy within 6 months of MRI (before or after MRI).
  • * Both genders.
  • * Age \> 18 years.
  • * Any racial/ethnic background.
  • * Previous history or current diagnosis of HCC or decompensation.
  • * Contraindications for MRI, including
  • * Medically unstable
  • * Intracranial clips
  • * Metal implants
  • * Suspected or confirmed metal in eyes
  • * Cardiac pacemaker, implanted defibrillator, other implanted electronic device
  • * Pregnancy: Pregnancy tests will be offered to women of childbearing age at no cost
  • * Severe claustrophobia

Ages Eligible for Study

18 Years to 89 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Icahn School of Medicine at Mount Sinai,

Sara Lewis, MD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Study Record Dates

2026-02-28