Evaluation of Uterine Fibroids by CEUS and SHAPE Pre and Post UAE

Description

This study goals are to determine the patterns of uterine fibroid vascularity pre and post UAE using CEUS resulting in an alternative to gadolinium-enhanced MRI that is less expensive, has less contra-indications and side effects, is real time, and noninvasive helping physicians to evaluate the result of UAE procedures. Also, this study will evaluate uterine fibroid pressures using SHAPE, comparing the results with normal myometrium tissue in order to determine its characteristics and tissue differences, which we believe will lead to the development of a new biomarker for the diagnosis and treatment of uterine fibroids.

Conditions

Uterine Fibroid

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Study Overview

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Study Details

Study overview

This study goals are to determine the patterns of uterine fibroid vascularity pre and post UAE using CEUS resulting in an alternative to gadolinium-enhanced MRI that is less expensive, has less contra-indications and side effects, is real time, and noninvasive helping physicians to evaluate the result of UAE procedures. Also, this study will evaluate uterine fibroid pressures using SHAPE, comparing the results with normal myometrium tissue in order to determine its characteristics and tissue differences, which we believe will lead to the development of a new biomarker for the diagnosis and treatment of uterine fibroids.

Evaluation of Uterine Fibroids by Contrast Enhanced Ultrasound (CEUS) and Subharmonic- Aided Pressure Estimation (SHAPE) Pre and Post-Uterine Artery Embolization (UAE)

Evaluation of Uterine Fibroids by CEUS and SHAPE Pre and Post UAE

Condition
Uterine Fibroid
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Thomas Jefferson University, Philadelphia, Pennsylvania, United States, 19107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be a female diagnosed with endometrial cancer and scheduled for UAE.
  • * Be over the age of 18 years.
  • * If the subject is of child-bearing potential, must have a negative pregnancy test.
  • * Be conscious and able to comply with study procedures.
  • * Have read and signed the IRB approved consent form for participating in the study.
  • * Females who are pregnant or nursing.
  • * Patients who have received an investigational drug in the 30 days before study drug administration, or will receive one within 72 hours afterwards.
  • * Patients who are medically unstable, patients who are seriously or terminally ill, and patients whose clinical course is unpredictable. For example:
  • * Patients on life support or in a critical care unit.
  • * Patients with clinically unstable cardiac arrhythmias, such as recurrent ventricular tachycardia.
  • * Patients with recent cerebral hemorrhage.
  • * Patients who have undergone surgery within 24 hours prior to the study sonographic examination.
  • * Patients with congenital heart defects.
  • * Patient with a known allergy to Definity.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Thomas Jefferson University,

Study Record Dates

2026-09-30