Connective Tissue Matrix Compared to Steroid Injections for Rotator Cuff Tendinopathy

Description

The goal of the study is to see which is better at treating patients which rotator cuff tendinopathy (RCT): a single injection of Connective Tissue Matrix boost (CTM) or a steroid shot. Patients will be randomized (like flipping a coin) to the treatment. Patients and researchers will be blinded (not know) what group the patients are in. Patients will come back to the study clinic at 6 weeks, 3 months and 6 months after the shot to answer questionnaires, have a physical exam, and complete physical function tests to check their shoulder.

Conditions

Rotator Cuff Tendinopathy

Study Overview

Study Details

Study overview

The goal of the study is to see which is better at treating patients which rotator cuff tendinopathy (RCT): a single injection of Connective Tissue Matrix boost (CTM) or a steroid shot. Patients will be randomized (like flipping a coin) to the treatment. Patients and researchers will be blinded (not know) what group the patients are in. Patients will come back to the study clinic at 6 weeks, 3 months and 6 months after the shot to answer questionnaires, have a physical exam, and complete physical function tests to check their shoulder.

Connective Tissue Matrix (CTM) Compared to Corticosteroid Injections: a Pilot Randomized Controlled Trial

Connective Tissue Matrix Compared to Steroid Injections for Rotator Cuff Tendinopathy

Condition
Rotator Cuff Tendinopathy
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Allegheny Health Network Federal North Medical Office Building, Pittsburgh, Pennsylvania, United States, 15212

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients aged 18-80 years old with rotator cuff tendinopathy
  • * A corticosteroid or CTM-type injection was determined by the clinician to be the proper medical treatment course and patient is willing to undergo the injection
  • * Patients with adhesive capsulitis
  • * Patients with acromio-clavicular joint impingement, retracted tears, significant labral lesions or significant glenohumeral arthrosis
  • * Patients with joint instability
  • * History of shoulder surgery or corticosteroid injection in the past 3 months
  • * Patients with a history of chronic steroid treatment for any medical reason
  • * Patients with medical conditions that may affect healing, such as
  • * End-stage renal disease
  • * Uncontrolled diabetes
  • * Peripheral vascular disease
  • * Severe and/or systemic immunocompromising conditions such as Lupus or HIV infection
  • * Patients who are pregnant or breast feeding

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute),

Study Record Dates

2025-12-31