A Study of Lung Cancer Screening in People With Unexplained Weight Loss

Description

The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss. The lung cancer screening will involve use of low-dose computed tomography (LDCT), a CT scan that gives off very low doses of radiation and can make detailed pictures of the lungs to help find tumors. The study researchers will also analyze participants' blood samples to determine if blood testing can be used to help to diagnose lung cancer.

Conditions

Lung Cancer Screening

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Study Overview

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Study Details

Study overview

The researchers are doing this study to see if people with unexplained weight loss who have lung cancer screening are more likely to have or develop lung cancer than people without unexplained weight loss. The lung cancer screening will involve use of low-dose computed tomography (LDCT), a CT scan that gives off very low doses of radiation and can make detailed pictures of the lungs to help find tumors. The study researchers will also analyze participants' blood samples to determine if blood testing can be used to help to diagnose lung cancer.

Enrichment of Lung Cancer Screening Through Unexplained Weight Loss (UWL) to Stage Shift and Improve Survival

A Study of Lung Cancer Screening in People With Unexplained Weight Loss

Condition
Lung Cancer Screening
Intervention / Treatment

-

Contacts and Locations

Basking Ridge

Memorial Sloan Kettering at Basking Ridge (All Protocol Activities), Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth (All Protocol Activities), Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen (All Protocol Activities), Montvale, New Jersey, United States, 07645

Bronx

Montefiore Health Systems (Montefiore Medical Center), Bronx, New York, United States, 10467

Commack

Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities), Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester (All Protocol Activities), Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States, 10065

Uniondale

Memorial Sloan Kettering Nassau (All Protocol Activities), Uniondale, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Eligible for American Cancer Society lung cancer screening, as follows:
  • * Age 50-80 years old
  • * At least 20-pack year history of smoking
  • * Medical record documentation of weight in an electronic medical record at enrollment and 12 months prior to enrollment, +/- 3 months.
  • * Weight loss of 3-10%, defined as UWL, in the prior 12 months +/- 3 months prior to enrollment, that cannot be attributed to an underlying medical condition at the discretion of the enrolling investigator
  • * Life expectancy greater than 1 year, per assessment of the treating clinician.
  • * Currently pregnant or trying to become pregnant via self-report
  • * Prior history of recent CT scan of the chest either through LDCT screening or with a scan of the chest (standard, not LDCT) performed within the past 12 months
  • * Prior history of NSCLC
  • * Currently undergoing or referred for diagnostic evaluation due to clinical suspicion for malignancy (e.g., referred to a medical or surgical oncologist, or scheduled for biopsy on the basis of a suspicious imaging abnormality).
  • * Patients with a germline pathogenic genetic variant who have undergone whole body MRI within the past 12 months
  • * Unable to comply with study procedures

Ages Eligible for Study

50 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Daniel Gomez, MD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2026-12