A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

Description

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolerate the study medicine.

Conditions

Obesity

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Study Overview

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Study Details

Study overview

The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07976016) for the potential treatment of obesity. The study will compare the experiences of participants taking the study medicine (PF-07976016) to those of participants who take placebo (a lookalike substance that contains no active study medicine). The aim is to measure the body's response to the study medicine, including any changes in participants' body weight and how well they tolerate the study medicine.

A PHASE 2A, RANDOMIZED, DOUBLE-BLIND, SPONSOR-OPEN, PLACEBO-CONTROLLED, PARALLEL GROUP, DOSE-RANGING STUDY OF PF-07976016 TO ASSESS SAFETY AND EFFICACY IN ADULT PARTICIPANTS WITH OBESITY

A Study to Learn About the Study Medicine Called PF-07976016 in Adults With Obesity

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

San Diego

Artemis Institute for Clinical Research, San Diego, California, United States, 92103

Jacksonville

Westside Center for Clinical Research, Jacksonville, Florida, United States, 32205

Miami

New Horizon Research Center, Miami, Florida, United States, 33165

Saint Augustine

St Johns Center for Clinical Research, Saint Augustine, Florida, United States, 32086

Union City

Rophe Adult and Pediatric Medicine/SKYCRNG, Union City, Georgia, United States, 30291

Honolulu

East-West Medical Research Institute, Honolulu, Hawaii, United States, 96814

Louisville

L-MARC Research Center, Louisville, Kentucky, United States, 40213

Rochester

Rochester Clinical Research, LLC, Rochester, New York, United States, 14609

Norman

Alliance for Multispecialty Research, LLC, Norman, Oklahoma, United States, 73069

Norman

Cornerstone Nutrition and Diabetes, Norman, Oklahoma, United States, 73069

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or non-pregnant, non-breastfeeding female, 18 to 74 years of age at Visit 1
  • * Body Mass Index ≥30.0 kg/m2 at Visit 1, with stable body weight, defined as \<5 kg change in the 12 weeks before Visit 1
  • * Eligible and willing to receive required background medicine
  • * Willing and able to comply with all study procedures
  • * Any medical or psychiatric condition or laboratory abnormality, or recent serious illness or hospitalization, that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study including diagnosis of type 2 diabetes mellitus, type 1 or secondary forms of diabetes.
  • * Use of any prohibited prior or concomitant medication(s)
  • * Presence of specified abnormalities on diagnostic assessments including clinical laboratory tests at Visit 1.

Ages Eligible for Study

18 Years to 74 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Pfizer,

Pfizer CT.gov Call Center, STUDY_DIRECTOR, Pfizer

Study Record Dates

2026-01-17