RECRUITING

A Study to Investigate the Safety, Tolerability, and Preliminary Efficacy with AION-301 Administered by Intravenous Infusion Compared with Placebo Administered by Intravenous Infusion Investigational Intervention in Participants Aged 35 to 75 Years of Age with Chronic Kidney Disease (CKD)

Conditions

Chronic Kidney Disease Stage 3 CKD AION-301 Stage 3 CKD Chronic Kidney Disease

Quick Navigation

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn about the safety (good or bad) of giving two AION-301 intravenous (IV) infusions, in adults with Stage 3 Chronic Kidney Disease (CKD). It will also help to learn if AION-301 reduces the symptoms of CKD and/or progression. The main questions it aims to answer are: * Do participants have medical problems (adverse events) after receiving two infusions of AION-301? * Do participants feel better (have reduced and/or delayed CKD symptoms)? * To learn about how AION-301 works in participants with CKD? Researchers will compare AION-301 to a placebo (a look-alike substance that contains no drug) to see if AION-301 works to treat Stage 3 CKD. Participants will: * Receive two infusions of AION-301 or placebo on two separate days (Day 0 and Day 4). * Receive oral vitamins at the clinic and to take at home for 90 days. * Visit the clinic for a minimum of 9 times, over 6 months for checkups and tests, but could be up to 12 times, over 24 months for checkups and tests.

Official Title

A Double-blinded, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of AION-301 Administered by Intravenous Infusion for the Treatment of Participants with Stage 3 Chronic Kidney Disease

Quick Facts

Study Start:2025-01-23

Study Completion:2027-12

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06721143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years to 75 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Patient is able to communicate well with the investigator, is capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol, understands all requirements of the study, and understands and signs the written ICF before any study-specific procedure. * Willing and able to comply with the scheduled visits and treatment plan. * Either biological sex * Participant must be 35 to 75 years of age inclusive, at the time of signing the informed consent. * Diagnosis of CKD stage 3, G3 (a and b): persistent eGFR between 30 and 59 mL/min/1.73 m² (at least 2 measures within that range in the preceding 3 months, including the one at screening visit), and persistent increased Albuminuria (at least 2 measures within 3 months, including 1 before screening and 1 at screening (criterion for increased Albuminuria at screening: ≥2 out of 3 repeat daily early morning samples at screening) (UACR ≥ 200 mg/g and \< than 5000 mg/g) * Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), and SGLT2 inhibitors (SGLT2i) unless such treatment is contraindicated or not tolerated\. Treatment dose must be stable for at least 3 months prior to the date of the screening. If a patient is on treatment with GLP-1 receptor agonist, he/she should be on a stable dose for at least 3 months before screening. Female subjects must not be breastfeeding and must have no intention to become pregnant during the study, and she will be required to use at least two FDA approved birth control during the study. The FDA-approved and cleared methods for birth control are listed below: * Permanent Sterilization * Long-Acting Reversible Contraceptives (LARC) * Contraceptive Injection * Short-Acting Hormonal Methods * Barrier Methods * Emergency Contraception * Any male subject must agree to use contraceptives and not donate sperm during the study. * Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.	* Prior transplant of any organ (including BM and stem cell transplant) or kidney transplant scheduled in the next 6 months. * Proteinuria\>5000 and or serum Albumin\< 2.5 g/dl. * Acute coronary syndrome, stroke or TIA or hospitalization for heart failure in previous 12 weeks or poorly controlled hypertension (≥160/100 mmHg at screening visit) or SBP\<90 at screening visit. * History of malignancy (except successfully treated squamous and basal cells skin carcinoma) within 5 years of screening. * History of atrial fibrillation (AF, AFib). * CKD due to genetic disorder. * History of systemic Autoimmune diseases like T1D, SLE or CKD caused by any autoimmune kidney disease. * Acute Kidney Injury (AKI) defined as increase in serum creatinine ≥1.5 times baseline in the previous 3 months or by presence of acute tubular injury in kidney biopsy in the previous 3 months. * Dialysis for acute renal failure within 12 weeks of screening visit. * Rapidly progressive kidney disease (eGFR reduction ≥ 30% over the last three months) * HbA1c ≥ 8.5%. * BMI ≥35 kg/m2. * Disorder of coagulation (including any history of thrombotic or thromboembolic disease) and/or long-term anti-coagulant therapy * History of Deep Vein Thrombosis (DVT) * History of Acute Pulmonary Embolism * History of solitary kidney. * On medications such as immunosuppressant, monoclonal antibodies, anabolic steroids, at the time of screening or in the previous 6 months and/or illicit drugs. * History of alcohol abuse or cigarette smoking in the previous 6 months. * Pregnancy or breast feeding at the time of screening, or with intention to become pregnant or breast-feeding during the course of the study, including the follow-up period. * History of liver disease, ALT and AST ≥3 x ULN, positive serology for Hepatitis B or Hepatitis C, HIV. * A significant medical history or abnormality at the physical exam that, in the judgment of the principal investigator, may interfere with the study. * Presence of any active infection, including COVID 19 * Any clinically significant pulmonary disease * History of hypersensitivity to study drug and/or any of its excipients. * Close affiliation with the investigational site; for example, a close relative of the investigator, dependent person (for example employee or student of the investigational site). * Panel Reactive Antibodies (PRA) \>0% (positive)

Inclusion Criteria

Exclusion Criteria

* Patient is able to communicate well with the investigator, is capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol, understands all requirements of the study, and understands and signs the written ICF before any study-specific procedure.
* Willing and able to comply with the scheduled visits and treatment plan.
* Either biological sex
* Participant must be 35 to 75 years of age inclusive, at the time of signing the informed consent.
* Diagnosis of CKD stage 3, G3 (a and b): persistent eGFR between 30 and 59 mL/min/1.73 m² (at least 2 measures within that range in the preceding 3 months, including the one at screening visit), and persistent increased Albuminuria (at least 2 measures within 3 months, including 1 before screening and 1 at screening (criterion for increased Albuminuria at screening: ≥2 out of 3 repeat daily early morning samples at screening) (UACR ≥ 200 mg/g and \< than 5000 mg/g)
* Treatment with maximum labelled or tolerated dose of a renin-angiotensin-aldosterone system (RAAS) blocking agent including an angiotensin converting enzyme (ACE) inhibitor or an angiotensin II receptor blocker (ARB), and SGLT2 inhibitors (SGLT2i) unless such treatment is contraindicated or not tolerated\*. Treatment dose must be stable for at least 3 months prior to the date of the screening. If a patient is on treatment with GLP-1 receptor agonist, he/she should be on a stable dose for at least 3 months before screening.
* Female subjects must not be breastfeeding and must have no intention to become pregnant during the study, and she will be required to use at least two FDA approved birth control during the study. The FDA-approved and cleared methods for birth control are listed below:
* Permanent Sterilization
* Long-Acting Reversible Contraceptives (LARC)
* Contraceptive Injection
* Short-Acting Hormonal Methods
* Barrier Methods
* Emergency Contraception
* Any male subject must agree to use contraceptives and not donate sperm during the study.
* Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.

* Prior transplant of any organ (including BM and stem cell transplant) or kidney transplant scheduled in the next 6 months.
* Proteinuria\>5000 and or serum Albumin\< 2.5 g/dl.
* Acute coronary syndrome, stroke or TIA or hospitalization for heart failure in previous 12 weeks or poorly controlled hypertension (≥160/100 mmHg at screening visit) or SBP\<90 at screening visit.
* History of malignancy (except successfully treated squamous and basal cells skin carcinoma) within 5 years of screening.
* History of atrial fibrillation (AF, AFib).
* CKD due to genetic disorder.
* History of systemic Autoimmune diseases like T1D, SLE or CKD caused by any autoimmune kidney disease.
* Acute Kidney Injury (AKI) defined as increase in serum creatinine ≥1.5 times baseline in the previous 3 months or by presence of acute tubular injury in kidney biopsy in the previous 3 months.
* Dialysis for acute renal failure within 12 weeks of screening visit.
* Rapidly progressive kidney disease (eGFR reduction ≥ 30% over the last three months)
* HbA1c ≥ 8.5%.
* BMI ≥35 kg/m2.
* Disorder of coagulation (including any history of thrombotic or thromboembolic disease) and/or long-term anti-coagulant therapy
* History of Deep Vein Thrombosis (DVT)
* History of Acute Pulmonary Embolism
* History of solitary kidney.
* On medications such as immunosuppressant, monoclonal antibodies, anabolic steroids, at the time of screening or in the previous 6 months and/or illicit drugs.
* History of alcohol abuse or cigarette smoking in the previous 6 months.
* Pregnancy or breast feeding at the time of screening, or with intention to become pregnant or breast-feeding during the course of the study, including the follow-up period.
* History of liver disease, ALT and AST ≥3 x ULN, positive serology for Hepatitis B or Hepatitis C, HIV.
* A significant medical history or abnormality at the physical exam that, in the judgment of the principal investigator, may interfere with the study.
* Presence of any active infection, including COVID 19
* Any clinically significant pulmonary disease
* History of hypersensitivity to study drug and/or any of its excipients.
* Close affiliation with the investigational site; for example, a close relative of the investigator, dependent person (for example employee or student of the investigational site).
* Panel Reactive Antibodies (PRA) \>0% (positive)

Contacts and Locations

Study Contact

Giacomo Lanzoni, PHD

CONTACT

+1786-285-9512

glanzoni@aionhealthspan.com

Desa Rae E Stanton-Pastore, MS

CONTACT

+1585-305-3850

dpastore@aionhealthspan.com

Study Locations (Sites)

University of Miami, Leonard M. Miller School of Medicine

Miami, Florida, 33136

United States

Collaborators and Investigators

Sponsor: AION Healthspan, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01-23

Study Completion Date2027-12

Study Record Updates

Study Start Date2025-01-23

Study Completion Date2027-12

Terms related to this study

Keywords Provided by Researchers

CKD
AION-301
Stage 3 CKD
Chronic Kidney Disease

Additional Relevant MeSH Terms

Chronic Kidney Disease Stage 3