A Study of MGC028 in Participants With Advanced Solid Tumors

Description

The goal of this clinical trial is to characterize the safety, tolerability, dose-limiting toxicities (DLT), and maximum tolerated dose (MTD) or maximum administered dose of MGC028 (if no MTD is defined). The study will enroll adult participants with relapsed or refractory, unresectable, locally advanced of metastatic solid tumors known to express ADAM9. The main question the study aims to answer is: * What types of side effects will participants experience when receiving MGC028? * Can MGC028 cause cancer to shrink, remain stable, or able to control disease progression of participants with advanced solid tumors? Participants will * Undergo screening procedures to determine eligibility * Receive study treatments initially every 3 weeks. * Have blood samples taken for routine and research tests * Have other examinations to check heart and lung function, and general health status * Be asked about any side effects that may be happening or other medications you are taking. The study doctor will provide treatment for side effects, if necessary. * Have the study doctor assess your tumor status at regular intervals to determine how you are responding to treatment.

Conditions

Advanced Solid Tumors, NSCLC Adenocarcinoma, Cholangiocarcinoma, Pancreatic Carcinoma, Colorectal Carcinoma

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to characterize the safety, tolerability, dose-limiting toxicities (DLT), and maximum tolerated dose (MTD) or maximum administered dose of MGC028 (if no MTD is defined). The study will enroll adult participants with relapsed or refractory, unresectable, locally advanced of metastatic solid tumors known to express ADAM9. The main question the study aims to answer is: * What types of side effects will participants experience when receiving MGC028? * Can MGC028 cause cancer to shrink, remain stable, or able to control disease progression of participants with advanced solid tumors? Participants will * Undergo screening procedures to determine eligibility * Receive study treatments initially every 3 weeks. * Have blood samples taken for routine and research tests * Have other examinations to check heart and lung function, and general health status * Be asked about any side effects that may be happening or other medications you are taking. The study doctor will provide treatment for side effects, if necessary. * Have the study doctor assess your tumor status at regular intervals to determine how you are responding to treatment.

A Phase 1, First-in-Human, Open Label, Dose Escalation and Cohort Expansion Study of MGC028 in Participants With Advanced Solid Tumors

A Study of MGC028 in Participants With Advanced Solid Tumors

Condition
Advanced Solid Tumors
Intervention / Treatment

-

Contacts and Locations

San Francisco

UCSF - Helen Diller Family Cancer Center, San Francisco, California, United States, 94115

Boston

Dana Farber/Harvard Cancer Center, Boston, Massachusetts, United States, 02115

Grand Rapids

South Texas Accelerated Research Therapeutics (START) Midwest, Grand Rapids, Michigan, United States, 49546

New York

Icahn School of Medicine at Mt. Sinai, New York, New York, United States, 10029

San Antonio

South Texas Accelerated Research Therapeutics (START) San Antonio, San Antonio, Texas, United States, 78229

West Valley City

South Texas Accelerated Research Therapeutics (START) Mountain Region, West Valley City, Utah, United States, 84119

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants in dose escalation or supplemental cohorts must have histologically proven unresectable, locally advanced or metastatic solid tumor limited to one of the following types: NSCLC adenocarcinoma, cholangiocarcinoma, colorectal carcinoma (CRC), or pancreatic carcinoma that is refractory to standard therapy, or for which standard therapy does not exist, has proven to be intolerable, or has been refused by the participant.
  • * Participants in expansion cohorts must have either
  • * NSCLC adenocarcinoma with
  • * progression on or following anti-PD-1/PD-L1 inhibitor, unless contraindicated
  • * progression on or following therapy for actionable mutations (e.g. EGFR or ALK mutations), if present
  • * no more than 2 prior lines of cytotoxic chemotherapy for advanced or metastatic disease.
  • * Pancreatic cancer
  • * following at least 1 systemic therapy
  • * no more than 2 prior lines of cytotoxic therapy for advanced or metastatic disease.
  • * Colorectal adenocarcinoma with
  • * Progression during or following standard therapy with a fluoropyrimidine-based chemotherapy, oxaliplatin and irinotecan unless contraindicated, refused or unavailable
  • * Progression after prior targeted treatment for CRC with actionable mutations such as EGFR, KRAS, BRAF and MSI- H/dMMR, if present.
  • * No more that 2 lines of cytotoxic chemotherapy for advanced or metastatic disease
  • * No more than 4 lines of systemic regimens for advanced or metastatic disease
  • * Participants must have at least one lesion that meets the definition of measurable disease by RECIST v1.1.
  • * Participants must have an available archival or formalin-fixed paraffin-embedded tumor tissue or be willing to undergo a biopsy procedure to obtain a fresh tumor sample.
  • * Participants have acceptable physical condition and laboratory values.
  • * Participants of childbearing potential must agree to use highly effective methods of birth control.
  • * Participants must not be pregnant, planning to be pregnant, or breastfeeding.
  • * Any underlying medical or psychiatric condition impairing participant's ability to receive, tolerate, or comply with the planned treatment or study procedures.
  • * Active brain metastases or leptomeningeal metastases.
  • * Prior stem cell, tissue, or solid organ transplant.
  • * Another malignancy that required treatment within the past 2 years, with the exception of those with a negligible risk of metastasis or death such as adequately treated non-melanomatous skin cancer, localized prostate cancer (Gleason Score \< 6), or carcinoma in situ.
  • * Active viral, bacterial, or fungal infection
  • * Prior treatment with ADAM9 targeted agent for cancer.
  • * Prior treatment with major surgery, mediastinal or lung radiation, vaccination with live virus vaccines, systemic cancer treatment, chimeric antigen receptor (CAR)-T cell therapy, or experimental treatment within 4 weeks of the start of study treatment.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

MacroGenics,

Pepi Pencheva, M.D., STUDY_DIRECTOR, MacroGenics

Study Record Dates

2027-04