RECRUITING

Polymer Induced Liquid Precursor (PILP) in Adults in With Dentin Caries

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn if polymer-induced liquid precursor (PILP) can be used safely to treat dentin caries (cavities) in adults. The main question it aims to answer is: Is PILP (conditioner or liner) safe in adult teeth with dental caries? Researchers will compare PILP to a placebo (a look-alike substance that contains no drug) to see if PILP safely treats cavities in teeth. Participants will: 1) Have PILP or placebo applied to their tooth prior to the placement of a filling in the tooth, 2) Complete two telephone calls within three months of filling placement and 3) Visit the clinic at three months and six months after the placement of the filling.

Official Title

Dentin Caries and Polymer-induced Liquid Precursor System (PILP): Adult Safety Study

Quick Facts

Study Start:2025-02-01
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06727110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 64 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Stated willingness to comply with all study procedures and availability for the duration of the study
  2. 2. Male or female, aged 18 to sixty-four
  3. 3. In good general health as evidenced by medical history (ASA 1 or 2)
  4. 4. With at least one posterior tooth with caries to dentin
  5. 1. The tooth must have a pulpal diagnosis of pulpal health (no irreversible pulpitis or periapical radiolucency)
  6. 2. The tooth should have no existing restorations
  7. 3. The caries should be a Class I or class V single surface lesion
  8. 4. The tooth should be planned for restoration with intra-coronal restoration (composite or RMGI restoration)
  9. 5. The tooth should be deemed as needing a restoration based on ICDAS (International Caries Detection and Assessment System)
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jean Star, DDS, MPH
CONTACT
415-514-9768
jean.star@ucsf.edu
Jessica Snider, MBA
CONTACT
4155146994
jessica.snider@ucsf.edu

Principal Investigator

Stefan Habelitz, PhD
PRINCIPAL_INVESTIGATOR
Stefan Habelitz, PhD

Study Locations (Sites)

University of California San Francisco, School of Dentistry
San Francisco, California, 94143
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Stefan Habelitz, PhD, PRINCIPAL_INVESTIGATOR, Stefan Habelitz, PhD

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-01
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2025-02-01
Study Completion Date2025-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Dental Caries