RECRUITING

A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a study of BMS-986490 as a monotherapy and in combination with bevacizumab in participants with select advanced solid tumors known to express CEACAM5.

Official Title

A Phase 1/2a, Multicenter, Open-label, First in Human Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors

Quick Facts

Study Start:2025-02-17
Study Completion:2029-12-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06730750

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Documented histologically or cytologically confirmed, advanced, unresectable/metastatic solid tumor measurable by RECIST v1.1.
  2. * CRC: Part 1A, Part 2A-CRC, Part 1B, and Part 2B:.
  3. * NSCLC: Part 2A-NSCLC/GC, 3L+ NSCLC:.
  1. * History of anaphylactic reactions to irinotecan and/or bevacizumab.
  2. * Previously received therapy targeting CEACAM5.
  3. * Grade ≥ 3 ILD/pneumonitis.
  4. * Other protocol-defined Inclusion/Exclusion criteria apply.

Contacts and Locations

Study Contact

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
CONTACT
855-907-3286
Clinical.Trials@bms.com
First line of the email MUST contain the NCT# and Site #.
CONTACT

Principal Investigator

Bristol-Myers Squibb
STUDY_DIRECTOR
Bristol-Myers Squibb

Study Locations (Sites)

Local Institution - 0007
Los Angeles, California, 90033
United States
START Midwest
Grand Rapids, Michigan, 49546
United States
Local Institution - 0004
Hackensack, New Jersey, 07601
United States
Local Institution - 0006
Pittsburgh, Pennsylvania, 15232
United States

Collaborators and Investigators

Sponsor: Bristol-Myers Squibb

  • Bristol-Myers Squibb, STUDY_DIRECTOR, Bristol-Myers Squibb

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-02-17
Study Completion Date2029-12-09

Study Record Updates

Study Start Date2025-02-17
Study Completion Date2029-12-09

Terms related to this study

Keywords Provided by Researchers

  • Colorectal Cancer (CRC)
  • Non-small Cell Lung cancer (NSCLC)
  • Gastric Cancer (GC)

Additional Relevant MeSH Terms

  • Advanced Solid Tumors