Multicenter ALS Imaging Study

Description

This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.

Conditions

Amyotrophic Lateral Sclerosis, ALS

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Study Overview

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Study Details

Study overview

This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.

Multicenter Longitudinal Imaging in ALS for Disease Biomarker Development

Multicenter ALS Imaging Study

Condition
Amyotrophic Lateral Sclerosis
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32608

Evanston

Northwestern University, Evanston, Illinois, United States, 60208

Minneapolis

University of Minnesota, Minneapolis, Minnesota, United States, 55455

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * \< 24 months since onset of symptoms
  • * Definite, probable, laboratory-supported probable, or possible ALS by El Escorial criteria OR definite, probable, or possible ALS by Awaji-Shima Criteria
  • * Forced vital capacity within the last 90 days ≥ 60% of the predicted value
  • * Able to consent for themselves
  • * Able to read and speak English
  • * Clear of any contraindications for MRI
  • * Individuals will be excluded if they have any condition that makes MRI unsafe or if they are unable to comply with instructions.
  • * All participants will undergo a neurologic examination at enrollment. Control participants with clinically significant abnormal findings on neurological examination will be excluded from the study.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Minnesota,

Pramod Pisharady, PhD, PRINCIPAL_INVESTIGATOR, University of Minnesota

Study Record Dates

2028-08-31