Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Description

This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Conditions

MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease

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Study Overview

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Study Details

Study overview

This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Non Alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis

Influence of Metabolic Syndrome on Endogenous Oxalate Synthesis

Condition
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham, Birmingham, Alabama, United States, 35294

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age \>18 years
  • * History of MASLD, with liver fat content \> 5%
  • * Normal kidney function
  • * Stable medication for at least 1 month for diabetes mellitus if any
  • * Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits
  • * Age \< 18 years
  • * Inaccurate 24-hour urine collections
  • * Liver fat content \<5%
  • * Liver cirrhosis
  • * Evidence of other chronic liver disease, viral hepatitis
  • * history of alcoholism within 2 years of enrollment
  • * Contra-indication to Magnetic Resonance Imaging
  • * Chronic kidney disease with estimated Glomerular Filtration rate \< 60 ml/min/1.73m2
  • * Type 1 Diabetes Mellitus or treatment with insulin
  • * Uncontrolled diabetes
  • * Pregnancy, lactation or intention to be
  • * Uncontrolled hypertension
  • * Use of weight loss medication, SGLT2 inhibitors, GLP-1 receptor agonists, osteoporosis medication, chronic NSAID
  • * History of gastric or intestinal surgery or resection that could potentially alter oxalate absorption
  • * Chronic fat malabsorption
  • * Use of immunosuppressive medications
  • * Known immuno-compromised status
  • * Active malignancy or treatment for malignanacy within the last 12 months

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Alabama at Birmingham,

Kyle D Wood, MD, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2026-12-31