RECRUITING

SNV4818 in Participants with Advanced Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is testing a new medicine, SNV4818, for people with advanced cancers. The researchers want to find out if SNV4818 is safe, well-tolerated, and effective in treating solid tumors. They are investigating different doses in order to find the safest and most effective one.

Official Title

A Phase 1, Open-Label Dose Escalation and Expansion Study of SNV4818 As Monotherapy or in Combination with Other Anticancer Agents in Participants with Advanced Solid Tumors

Quick Facts

Study Start:2025-01
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06736704

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Advanced or metastatic solid tumor with an activating PIK3CA mutation.
  2. * Refractory to or intolerant of available therapies
  3. * Disease measurable by RECIST 1.1 criteria, or disease evaluable by clinically relevant tumor biomarkers in blood.
  4. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  1. * Diagnosis of a primary CNS malignancy
  2. * Active brain metastases or carcinomatous meningitis
  3. * Type 1 diabetes mellitus or uncontrolled type 2 diabetes mellitus
  4. * Inadequate organ function
  5. * Clinically significant ECG abnormalities, including QTcF ≥ 470 ms

Contacts and Locations

Study Contact

Robert Casper
CONTACT
443-764-9527
rcasper@synnovationtx.com

Study Locations (Sites)

The University of Texas M.D. Anderson Cancer Center
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Synnovation Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01
Study Completion Date2026-12

Study Record Updates

Study Start Date2025-01
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Advanced Solid Tumors