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Enhancing Physical Function in Older Adults With Chronic Kidney Disease

Description

The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.

Conditions

Chronic Kidney Diseases
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Related Conditions:

Chronic Kidney Diseases

Study Overview

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Study Details

Study overview

The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.

Enhancing Physical Function in Older Adults With Chronic Kidney Disease (EPIC): A Pilot Randomized Controlled Trial

Enhancing Physical Function in Older Adults With Chronic Kidney Disease

Condition
Chronic Kidney Diseases
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Chronic kidney disease stage 4-5
  • * Capacity to complete physical exercise
  • * Lives within 20 miles of Wake Forest Reynolda Campus
  • * Fluent English speaker
  • * Does not plan to travel outside of home area for an extended period of time during study
  • * Willing to be randomized to either intervention group
  • * Short physical performance battery score of 9 or higher
  • * Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
  • * Dependent on walking device
  • * Current participation in a resistance training program
  • * Joint replacement or orthopedic surgery in the previous 6-months or planning to have surgery in the next 6- months
  • * Absolute contraindications to exercise testing according to ACSM:
  • * Parkinson's disease
  • * Respiratory disease requiring oxygen
  • * Cancer requiring treatment
  • * Currently receiving physical therapy or cardiopulmonary rehabilitation
  • * Type I or insulin dependent Type II Diabetes
  • * Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
  • * Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence

Ages Eligible for Study

65 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wake Forest University Health Sciences,

Eliott Arroyo, PhD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

2026-07