RECRUITING

Enhancing Physical Function in Older Adults With Chronic Kidney Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this pilot randomized controlled trial is to examine the feasibility and safety of a 12-week high-velocity resistance training (HVRT) intervention in older adults with chronic kidney disease (CKD) stages 4-5 and to generate preliminary data to inform a future study investigating the efficacy of HVRT for improving muscle power and physical function. Researchers will compare HVRT to an attention control condition consisting of weekly group sessions covering topics on healthy lifestyle. This study seeks to: 1. Determine whether implementing an HVRT intervention is feasible and safe for mobility-limited older adults with advanced CKD. 2. Collect preliminary data on the efficacy of HVRT for improving muscle power and physical function in mobility-limited older adults with advanced CKD.

Official Title

Enhancing Physical Function in Older Adults With Chronic Kidney Disease (EPIC): A Pilot Randomized Controlled Trial

Quick Facts

Study Start:2025-07-31
Study Completion:2026-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06738394

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Chronic kidney disease stage 4-5
  2. * Capacity to complete physical exercise
  3. * Lives within 20 miles of Wake Forest Reynolda Campus
  4. * Fluent English speaker
  5. * Does not plan to travel outside of home area for an extended period of time during study
  6. * Willing to be randomized to either intervention group
  7. * Short physical performance battery score of 9 or higher
  1. * Receiving renal replacement therapy (e.g. hemodialysis, peritoneal dialysis) or anticipated to start renal replacement therapy in the next 6 months
  2. * Dependent on walking device
  3. * Current participation in a resistance training program
  4. * Joint replacement or orthopedic surgery in the previous 6-months or planning to have surgery in the next 6- months
  5. * Absolute contraindications to exercise testing according to ACSM:
  6. * Parkinson's disease
  7. * Respiratory disease requiring oxygen
  8. * Cancer requiring treatment
  9. * Currently receiving physical therapy or cardiopulmonary rehabilitation
  10. * Type I or insulin dependent Type II Diabetes
  11. * Scoring below 32 points on the Telephone Interview for Cognitive Status (TICS)
  12. * Site PI/Study Clinician discretion regarding medical status, appropriateness of participation or concern about intervention adherence

Contacts and Locations

Study Contact

Jenna Lauderback
CONTACT
336-758-3784
epicstudy@wfu.edu

Principal Investigator

Eliott Arroyo, PhD
PRINCIPAL_INVESTIGATOR
Wake Forest University Health Sciences

Study Locations (Sites)

Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States

Collaborators and Investigators

Sponsor: Wake Forest University Health Sciences

  • Eliott Arroyo, PhD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-31
Study Completion Date2026-07

Study Record Updates

Study Start Date2025-07-31
Study Completion Date2026-07

Terms related to this study

Keywords Provided by Researchers

  • kidney disease
  • resistance training
  • older adults

Additional Relevant MeSH Terms

  • Chronic Kidney Diseases