RECRUITING

The INSPIRE Study: Intervention Strategies for Preserving Intellectual Resilience and Engagement

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Conditions

DementiaAlzheimer

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The INSPIRE Study, initiated by the Healthy Minds Initiative, is a community-based research project aimed at demonstrating the impact of lifestyle factors on cognitive health and the prevention of dementia. Conducted in collaboration with the American College of Lifestyle Medicine, Charles Drew University, UCLA, Stanford University and Crenshaw Christian Center, this study focuses on African American communities that are disproportionately affected by lifestyle-dependent diseases. The study involves 2,000 participants aged 55 and older and aims to directly address these disparities by implementing targeted interventions to enhance cognitive function and overall brain health.

Official Title

Intervention Strategies for Preserving Intellectual Resilience and Engagement

Quick Facts

Study Start:2025-06-01
Study Completion:2027-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06741865

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age: Participants must be 55 years of age or older.
  2. * Ethnicity: Focused on African American individuals, but not exclusive.
  3. * Cognitive Status: Participants must have normal cognitive status, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI).
  4. * Language: Participants must be fluent in English.
  5. * Location: Must reside in the Crenshaw, California area or be able to attend study-related activities in this location.
  6. * Willingness to Participate: Participants must be willing to adhere to the study protocol, including attending assessments, participating in interventions, and completing questionnaires.
  1. * Cognitive Decline: Diagnosis of dementia or severe cognitive impairment that would interfere with the ability to participate in the study.
  2. * Physical Limitations: Any physical or medical condition that would preclude participation in the lifestyle interventions (e.g., severe mobility issues).
  3. * Recent Cancer Diagnosis: Diagnosis of cancer within the last three years, excluding stable cases of basal cell or squamous cell carcinoma of the skin, or stable prostate cancer.
  4. * Pregnancy: Current pregnancy or planning to become pregnant during the study period.
  5. * Mental Health: Diagnosis of severe psychiatric disorders such as schizophrenia or bipolar disorder that might interfere with participation.
  6. * Substance Abuse: Current substance abuse or dependency that could impact participation.
  7. * Hearing Impairment: Uncorrected hearing loss that would limit the ability to communicate and participate in the study.
  8. * Non-English Speaking: Inability to participate in English-language oral and written cognitive assessments.
  9. * Participation in Another Study: Currently enrolled in another clinical trial that could interfere with the INSPIRE Study.
  10. * Life expectancy less than 3 years
  11. * Unwillingness to share medical and laboratory information.

Contacts and Locations

Study Contact

Dean Sherzai, MD, PhD
CONTACT
949-383-6729
dean@healthymindsinitiative.org
Caroline Segalla, BA
CONTACT
808-333-2883
caroline@healthymindsinitiative.org

Principal Investigator

Dean Sherzai, MD, PhD
PRINCIPAL_INVESTIGATOR
Healthy Minds Initiative

Study Locations (Sites)

Crenshaw Christian Center
Los Angeles, California, 90044
United States

Collaborators and Investigators

Sponsor: Healthy Minds Initiative

  • Dean Sherzai, MD, PhD, PRINCIPAL_INVESTIGATOR, Healthy Minds Initiative

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-01
Study Completion Date2027-12-01

Study Record Updates

Study Start Date2025-06-01
Study Completion Date2027-12-01

Terms related to this study

Keywords Provided by Researchers

  • Dementia
  • Alzheimer

Additional Relevant MeSH Terms

  • Dementia