Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women

Description

The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.

Conditions

Estrogen, Premenopause

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Study Overview

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Study Details

Study overview

The purpose of this study is to identify the impact of estradiol (E2) on the associations between (a) responsivity to daily stress or (b) sleep variability with vascular function in midlife premenopausal women.

Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women

Disentangling the Effects of Daily Stress, Sleep, and Sex Hormones on Accelerated Vascular Aging in Midlife Women

Condition
Estrogen
Intervention / Treatment

-

Contacts and Locations

Newark

University of Delaware, Newark, Delaware, United States, 19713

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female
  • * Age 40-55
  • * Premenopausal
  • * Pregnancy (including a positive urine pregnancy test), planning to become pregnant, or breast-feeding
  • * Peri- or post-menopausal
  • * Unstable or diagnosed chronic clinical disease, including cardiovascular, metabolic, renal, hepatic, autonomic, autoimmune, or dermatological disease
  • * Current or lifetime major psychiatric illness (e.g., major depressive disorder, bipolar disorder, schizophrenia, eating disorders)
  • * History of hysterectomy (complete or partial), polycystic ovary syndrome, endometrial hyperplasia, irregular menstrual cycles, or endometrial ablation
  • * Suspected potential presence of obstructive sleep apnea (STOP-Bang score \>3) or insomnia (Insomnia Severity Index score \>15)
  • * Current or recent (within 8 wks) use of medications that could conceivably alter cardiovascular function or sleep health
  • * Changes or alterations in medication status (starting a new, additional, or different medication or changing the dose of a current medication)
  • * Body mass index \>35 kg/m2
  • * Tobacco or nicotine use, including vaping and electronic cigarettes
  • * Working night-time or rotating shift work within the previous 3 months
  • * Trans-meridian travel during study enrollment (inclusive of the entire duration of enrollment and the period between testing cycles)
  • * Known allergies to pharmacological agents/drugs
  • * Current use of long-acting reversible contraception (LARC; e.g., IUDs, birth control implants)
  • * Known latex allergy

Ages Eligible for Study

40 Years to 55 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Delaware,

Jody Greaney, PhD, PRINCIPAL_INVESTIGATOR, University of Delaware

Study Record Dates

2027-10