RECRUITING

Decision-Making in Schizophrenia: a Combined Neuroimaging and Experience Sampling Study

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Conditions

SchizophreniaSchizoaffective DisorderControl SubjectsCognitive StrategyEmotion RegulationPsychosisfunctional MRI

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn if attention and ways of thinking impact decision-making and brain processes related to decision-making in people with schizophrenia or schizoaffective disorder relative to people without either condition. It will also learn how brain functioning during decision-making relates to real-world decisions made during daily life. The main questions it aims to answer are: * Does paying attention to specific information impact decision-making and brain processes? * Does thinking in a certain way according to specific 'thinking strategies' improve brain processes related to decision-making? * Does brain functioning during decision-making relate to real-world choices to engage in activities? Researchers will compare brain functioning and decision-making on computer tasks of gambling after participants have been trained to use a positive thinking strategy. They will compare what is different in the brain and behavior when participants use this strategy and when they do not. Participants will also answer brief surveys about activities and feelings for a week in their daily lives. Participants will: * Complete several hours of clinical interviewing, cognitive tests, and surveys of about symptoms, experiences, and personality * Complete computer tasks about gambling decisions during MRI brain scanning and while having their visual attention measured using eye-tracking * Complete brief surveys about their activities and feelings 5 times a day for 1 week using a cell phone. Each survey only take several minutes.

Official Title

Promoting Adaptive Decision-Making in Schizophrenia Through Improved Evidence Integration: a Combined Neuroimaging and Experience Sampling Study

Quick Facts

Study Start:2024-12
Study Completion:2026-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06745479

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Between ages of 18-45.
  2. 2. Have capacity to provide informed consent
  3. 3. Fluent communication in English
  4. 4. Willingness and ability to follow study requirements, as evidenced by an ability to provide written or virtual informed consent and read, and complete, study procedures.
  5. 5. Cognitive ability to understand tasks and estimated IQ greater than 70.
  1. 1. Self-disclosed or noticeable intoxication from alcohol or illicit drugs (e.g., arriving to participate in the study drunk/high)
  2. 2. Self-disclosure of consistent current substance use other than nicotine, alcohol, or cannabis (e.g. cocaine, heroin).
  3. 3. Many-year history of severely disordered substance use other than nicotine/tobacco (determined via interview)
  4. 4. Significant physical health disorder, robust physical health conditions, neurological disease/disorder (e.g., Parkinson's, history of strokes).
  5. 5. History of traumatic brain injury, head injury resulting in loss of consciousness for an extended duration or with noted neurobehavioral consequences.
  6. 6. History of electroconvulsive therapy
  7. 7. History of seizures or epilepsy.
  8. 8. Currently untreated or unstable psychiatric and medical conditions.
  9. 9. Intellectual disability
  10. 10. Contra indications for MR imaging
  11. 1. Pervasive history of problematic substance use (other than nicotine or alcohol) as defined by meeting DSM-5 criteria for a substance use disorder.
  12. 2. Diagnosis of, or first-degree relative with, significant psychiatric disorder (e.g., bipolar disorder, psychotic disorder, or Cluster A personality disorder).

Contacts and Locations

Study Contact

Pariya Chanthasensack, BS
CONTACT
732-235-6438
CANL@rwjms.rutgers.edu
John Purcell, PhD
CONTACT
732-235-6438
jrp345@rwjms.rutgers.edu

Principal Investigator

David Zald, PhD
PRINCIPAL_INVESTIGATOR
Rutgers University

Study Locations (Sites)

Center for Advanced Human Brain Imaging Research
Piscataway, New Jersey, 08854
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • David Zald, PhD, PRINCIPAL_INVESTIGATOR, Rutgers University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12
Study Completion Date2026-07

Study Record Updates

Study Start Date2024-12
Study Completion Date2026-07

Terms related to this study

Keywords Provided by Researchers

  • Cognitive Strategy
  • Emotion Regulation
  • Psychosis
  • Schizophrenia
  • functional MRI

Additional Relevant MeSH Terms

  • Schizophrenia
  • Schizoaffective Disorder
  • Control Subjects