Phosphatidylethanol and Other Ethanol Consumption Markers

Description

This study is intended to help the investigators understand how a biomarker found in the blood may be used to better identify the quantity and different patterns of alcohol use. The investigators hope that the results of this study will help identify the uses of alcohol-use markers in the blood in future alcohol prevention and treatment programs. It is hoped that the information learned from this study will benefit other people in the future. The study participants will come into the lab and will (1) consume alcohol in the lab designed to produce a peak blood alcohol concentration of 0.06% and have blood collected over 6 hours followed by abstinence for 10 days to give a small blood sample 4 times and (2) to give a small amount of blood 5 times within 28 days (naturalistic drinking) and provide answers about alcohol use.

Conditions

Healthy Volunteer, Alcohol Consumption

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Study Overview

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Study Details

Study overview

This study is intended to help the investigators understand how a biomarker found in the blood may be used to better identify the quantity and different patterns of alcohol use. The investigators hope that the results of this study will help identify the uses of alcohol-use markers in the blood in future alcohol prevention and treatment programs. It is hoped that the information learned from this study will benefit other people in the future. The study participants will come into the lab and will (1) consume alcohol in the lab designed to produce a peak blood alcohol concentration of 0.06% and have blood collected over 6 hours followed by abstinence for 10 days to give a small blood sample 4 times and (2) to give a small amount of blood 5 times within 28 days (naturalistic drinking) and provide answers about alcohol use.

Phosphatidylethanol and Other Ethanol Consumption Markers

Phosphatidylethanol and Other Ethanol Consumption Markers

Condition
Healthy Volunteer
Intervention / Treatment

-

Contacts and Locations

Denton

University of North Texas, Denton, Texas, United States, 76201

San Antonio

University of Texas Health Science Center San Antonio, San Antonio, Texas, United States, 78229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. are ≥ 21 years old;
  • 2. are height and weight proportionate (body mass index 18-30); and
  • 3. report drinking on \> 1 days in the last month, with at least one day equal to at least achieving \~0.06% BAC.
  • 1. have significant current or predicted alcohol withdrawal symptoms (CIWA-AR scores ≥ 10);
  • 2. are currently in alcohol treatment;
  • 3. have substance use disorder (except nicotine, and/or caffeine);
  • 4. have a medical condition that would contraindicate participation (a positive urine pregnancy test, self-reported scheduled surgery or liver disease);
  • 5. are currently breast feeding;
  • 6. have a presence of a DSM-5 psychiatric disorder with symptoms of psychosis and/or delirium; or
  • 7. are unable to comprehend the informed consent process or study instructions.

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

The University of Texas Health Science Center at San Antonio,

Nathalie Hill-Kapturczak, PhD, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center at San Antonio

Donald Dougherty, PhD, PRINCIPAL_INVESTIGATOR, University of North Texas Health Science Center

Study Record Dates

2029-06