Opioids, Low Nicotine Cigarettes, and Chronic Pain

Description

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Conditions

Chronic Pain, Tobacco Use, Opioid Substitution Treatment

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals With Opioid Use Disorder and Chronic Pain

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Condition
Chronic Pain
Intervention / Treatment

-

Contacts and Locations

Durham

North Pavilion, Durham, North Carolina, United States, 27705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 21+ years who smoke cigarettes daily
  • * Chronic non-cancer musculoskeletal pain secondary to structural changes (e.g., low back pain, osteoarthritis)
  • * Have received stable office-based buprenorphine treatment for opioid use disorder for at least 30 days
  • * Self-report smoking at least 10 cigarettes/day
  • * Expired breath carbon monoxide (CO) level \>8 ppm
  • * Have a smartphone capable of running software for ecological momentary assessment
  • * Open to exploring the possibility of quitting smoking
  • * Pain specifically due to cancer
  • * Other significant health problems
  • * Major surgery within the past 6 months or planned surgery within the timeframe of the study
  • * Current disability litigation
  • * Use of electronic cigarettes or other non-cigarette tobacco products \> 9 of the past 30 days
  • * Current use of nicotine replacement therapy or other cessation treatment
  • * Current daily or near-daily cannabis use
  • * History of psychotic disorder
  • * Acute suicidality or current unstable psychiatric disorder
  • * Positive pregnancy test
  • * Actively seeking smoking cessation treatment

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Duke University,

Maggie Sweitzer, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2027-09