A Study to Evaluate the Efficacy, Safety, and Tolerability of IMVT-1402 in Adult Participants With Active, Difficult to Treat Rheumatoid Arthritis

Eligibility Criteria

• * Diagnosis of 'definite RA' according to the 2010 ACR/ European Alliance of Associations for Rheumatology (EULAR) Rheumatoid Arthritis Classification Criteria.
• * Greater than or equal to 6/68 TJC and ≥ 6/66 SJC at both Screening and Baseline visits.
• * C-reactive protein ≥ 1.5 × upper limit of normal (ULN) at Screening Visit.
• * DAS28-CRP \> 4.1 at the Screening Visit.
• * Elevated immunoglobulin G (IgG) + ACPA at the Screening Visit.
• * Inadequate response to at least 2 classes of biologic/targeted synthetic DMARDs.
• * Have received rituximab and experienced insufficient efficacy or loss of efficacy
• * History of any chronic inflammatory arthritis with onset prior to age 18 or history of acute inflammatory joint disease of different origin from RA.
• * Active malignancy or history of malignancy within 5 years prior to Screening Visit.
• * Medical history of primary immunodeficiency, T cell or humoral, including common variable immunodeficiency.
• * Used any non-immunosuppressive Fc-based therapeutic protein (e.g., mAb or Fc-fusion protein) within 4 weeks prior to or at Screening Visit.
• * Used any anti-FcRn treatment within 2 months prior to or at Screening Visit or have a documented history of non-response to prior anti-FcRn treatment.