Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease

Description

This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory strategy training to improve adherence to Cogmed in youth with sickle cell disease ages 7-16 years.

Conditions

Sickle Cell Disease

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Study Overview

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Study Details

Study overview

This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory strategy training to improve adherence to Cogmed in youth with sickle cell disease ages 7-16 years.

Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell (ALL IN)

Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease

Condition
Sickle Cell Disease
Intervention / Treatment

-

Contacts and Locations

Washington

Children's National Hospital, Washington, District of Columbia, United States, 20010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Diagnosis of sickle cell disease (any genotype).
  • 2. Between ages 7-16 years old.
  • 3. Patients will only enter the treatment phase if they score \>1 SD below the normative mean on at least one standardized working memory assessment (i.e., Digit Span or Spatial Span subtests) or demonstrate a relative weakness in working memory (\>1 SD below the estimated IQ).
  • 1. Motor, visual, or auditory impairment that prevents computer use.
  • 2. Diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in the cognitive training.
  • 3. History of photosensitive seizures.
  • 4. Insufficient English fluency.
  • 5. Recent initiation or dose adjustment of a stimulant medication to treat attention problems (\< 30 days).

Ages Eligible for Study

7 Years to 16 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Children's National Research Institute,

Steven Hardy, PhD, PRINCIPAL_INVESTIGATOR, Children's National Research Institute

Study Record Dates

2026-12