RECRUITING

Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

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Conditions

Left Ventricular Systolic Dysfunction

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).

Official Title

Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

Quick Facts

Study Start:2025-01
Study Completion:2027-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06770062

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age \>= 18
  2. * Male or Female
  3. * A diagnosis of severe chronic primary mitral regurgitation
  4. * Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
  5. * Patients must have the ability to consent or have an appropriate representative available to do so.
  1. * Prior valve intervention,
  2. * Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
  3. * Concomitant \>= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
  4. * History of prior myocardial infarction
  5. * History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
  6. * Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
  7. * Implantable devices that would be a contraindication to MRI
  8. * Severe allergy to gadolinium MRI contrast

Contacts and Locations

Study Contact

Cardiovascular Surgical Research
CONTACT
(507) 266-7982
cvsurgresearch@mayo.edu

Principal Investigator

Arman Arghami, MD, MPH
PRINCIPAL_INVESTIGATOR
Mayo Clinic
Alex Bratt, MD
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Arman Arghami, MD, MPH, PRINCIPAL_INVESTIGATOR, Mayo Clinic
  • Alex Bratt, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-01
Study Completion Date2027-01

Study Record Updates

Study Start Date2025-01
Study Completion Date2027-01

Terms related to this study

Additional Relevant MeSH Terms

  • Left Ventricular Systolic Dysfunction