Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

Description

The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).

Conditions

Left Ventricular Systolic Dysfunction

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Study Overview

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Study Details

Study overview

The purpose of this research is to determine the feasibility of a larger, future study proposing a multimodal approach using cardiac CT and MRI to assess the risk of developing left ventricular (LV) systolic dysfunction in patients with mitral regurgitation (MR).

Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

Multimodality Evaluation of Left Ventricular Remodeling In Mitral Regurgitation: A Pilot Study

Condition
Left Ventricular Systolic Dysfunction
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \>= 18
  • * Male or Female
  • * A diagnosis of severe chronic primary mitral regurgitation
  • * Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
  • * Patients must have the ability to consent or have an appropriate representative available to do so.
  • * Prior valve intervention,
  • * Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
  • * Concomitant \>= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
  • * History of prior myocardial infarction
  • * History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
  • * Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
  • * Implantable devices that would be a contraindication to MRI
  • * Severe allergy to gadolinium MRI contrast

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Arman Arghami, MD, MPH, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Alex Bratt, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2027-01