Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease

Description

This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.

Conditions

Parkinson&Amp;#39;s Disease

Study Overview

Study Details

Study overview

This is a research study investigating elevated homocysteine in the blood of patients with Parkinson's disease who are currently receiving treatment with levodopa. We are evaluating if elevated homocysteine can be corrected using open label B vitamin therapy, as well as the impact of homocysteine levels on cognitive function.

Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease

Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease

Condition
Parkinson&Amp;#39;s Disease
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health & Science University (OHSU), Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Diagnosis of probable Parkinson's Disease according to Movement Disorders Society criteria.
  • 2. Currently treated with levodopa at a minimum dose of 300 mg/day
  • 3. Montreal Cognitive Assessment (MOCA) ≥15
  • 4. Demonstrated capacity to provide informed consent.
  • 5. 40-90 years of age
  • 6. Estimated glomerular filtration rate ≥60
  • 7. Absence of uncontrolled hypertension in medical history
  • 8. Absence of insulin use

Ages Eligible for Study

40 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Oregon Health and Science University,

Joseph Quinn, MD, PRINCIPAL_INVESTIGATOR, Oregon Health & Science University (OHSU)

Study Record Dates

2025-12-31