RECRUITING

Vancomycin Reduction Practices (VRP) in the NICU

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Conditions

Antibiotic StewardshipNeonatal Sepsis, Late-OnsetVancomycinimplementation study

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit \& feedback, and use of a clinical decision support tool.

Official Title

Implementing Vancomycin Reducing Practices (VRP) in Preterm Infants

Quick Facts

Study Start:2025-06-02
Study Completion:2027-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06772675

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Level III NICU
  2. * Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN)
  3. * Recruited by study team
  1. * Site not recruited for the study

Contacts and Locations

Study Contact

Kayla Gilpin
CONTACT
215-573-3976
kayla.gilpin@pennmedicine.upenn.edu
Hanna Rosewood
CONTACT
267-271-8300
rosewoodh@chop.edu

Principal Investigator

Sagori Mukhopadhyay, MD, MMSc
PRINCIPAL_INVESTIGATOR
Children's Hospital of Philadelphia

Study Locations (Sites)

Kaiser Permanente Modesto Medical Center
Modesto, California, 95356
United States
Kaiser Permanente East Bay - Oakland Medical Center
Oakland, California, 94611
United States
Kaiser Permanente Roseville Medical Center
Roseville, California, 95661
United States
Kaiser Permanente San Francisco Medical Center
San Francisco, California, 94115
United States
Kaiser Permanente San Leandro Medical Center
San Leandro, California, 94577
United States
Kaiser Permanente Santa Clara Medical Center
Santa Clara, California, 95051
United States
Kaiser Permanente Walnut Creek Medical Center
Walnut Creek, California, 94596
United States
Medical Center of Princeton
Plainsboro, New Jersey, 08536
United States
Virtua Voorhees
Voorhees, New Jersey, 08043
United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
United States
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
Pennsylvania Hospital
Philadelphia, Pennsylvania, 19107
United States
Chester County Hospital
West Chester, Pennsylvania, 19380
United States

Collaborators and Investigators

Sponsor: Children's Hospital of Philadelphia

  • Sagori Mukhopadhyay, MD, MMSc, PRINCIPAL_INVESTIGATOR, Children's Hospital of Philadelphia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-02
Study Completion Date2027-09

Study Record Updates

Study Start Date2025-06-02
Study Completion Date2027-09

Terms related to this study

Keywords Provided by Researchers

  • implementation study

Additional Relevant MeSH Terms

  • Antibiotic Stewardship
  • Neonatal Sepsis, Late-Onset
  • Vancomycin