RECRUITING

Cognitive Reappraisal Training for Borderline Personality (BPD)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Previous work by the group convinced the researchers to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.

Official Title

Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients

Quick Facts

Study Start:2024-11-15
Study Completion:2027-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06772831

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent.
  2. * Participants will be between the ages of 18 and 55.
  3. * Within these requirements, the inclusion and exclusion criteria do not reflect participation based on gender or racial/ethnic group. The targeted/planned enrollment is a reflection of previous recruitment of female and ethnic minorities in other studies conducted by the PI and their colleagues and includes representations of both genders and all minorities.
  1. * Participants will not meet criteria for Schizotypal Personality Disorder or Avoidant Personality Disorder.
  2. * Participants currently meeting criteria for Major Depressive Disorder will be excluded.
  3. * BPD participants will not meet DSM-5 criteria for past or present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance use disorder within the past 6 months, organic mental syndromes, head trauma, schizotypal personality disorder, avoidant personality disorder, CNS neurological disease, or seizure disorder. Participants meeting criteria for a non-IV substance use disorder more than 6 months prior to enrollment will not be excluded. This study allows patients who are currently taking psychotropic medications or are in psychotherapy, so long as there has been no change in medication or psychotherapy over the preceding two months.
  4. * Participants currently meeting criteria for major depressive disorder.
  5. * Participants meeting criteria for substance use disorder within the last 6 months or of an IV-substance use disorder at any time.
  6. * Participants may not have a pacemaker, surgical clips, any metallic implants, or shrapnel fragments that would contraindicate MRI scanning.
  7. * Pregnant women.

Contacts and Locations

Study Contact

Harold W Koenigsberg, MD
CONTACT
718-584-9000
harold.koenigsberg@mssm.edu
Brian B Kang, BA
CONTACT
212-241-9775
brian.kang@mssm.edu

Principal Investigator

Harold W Koenigsberg, MD
PRINCIPAL_INVESTIGATOR
Icahn School of Medicine at Mount Sinai

Study Locations (Sites)

Icahn School of Medicine at Mount Sinai
New York, New York, 10029
United States

Collaborators and Investigators

Sponsor: Icahn School of Medicine at Mount Sinai

  • Harold W Koenigsberg, MD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-15
Study Completion Date2027-07-31

Study Record Updates

Study Start Date2024-11-15
Study Completion Date2027-07-31

Terms related to this study

Keywords Provided by Researchers

  • BPD
  • Treatment
  • fMRI
  • Cognitive Reappraisal
  • Emotion Regulation
  • Borderline Personality

Additional Relevant MeSH Terms

  • Borderline Personality Disorder