RECRUITING

Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balance Problems

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to learn if manipulating the brain using magnets works to treat balance impairment, a major cause of falls, in older adults with balance problems. The technique to manipulate the brain using magnets is known as transcranial magnetic stimulation or TMS. The main questions this study aims to answer are: * How does TMS change communication between brain areas? * Does TMS improve balance ability in older adults with balance problems? Researchers will compare the TMS group to a placebo group to see if manipulating the brain using magnets works to treat balance impairment. Participants will: * Receive TMS or placebo stimulation for 4 weeks. * Visit the laboratory for checkups and tests 3 times.

Official Title

Treating Balance Impairment of the Elderly With TMS-induced Brain Connectivity

Quick Facts

Study Start:2025-04-30
Study Completion:2026-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06779188

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. 1. Inability to provide informed consent.
  2. 2. Non-English speaking.
  3. 3. Have contraindications to TMS based on TMS Adult Safety Screen (e.g., pregnancy, metal in the brain/skull, neurostimulator, pacemaker, infusion device, medication to treat mental illness)
  4. 4. Unintentional weight loss of ≥10 pounds over the past year.
  5. 5. Severe uncontrolled hypertension, or uncontrolled diabetes.
  6. 6. Poor cognitive status (Montreal Cognitive Assessment (MoCA) score ≥ 26)
  7. 7. Untreated depression or Geriatric Depression Scale score on 15 item scale \>7
  8. 8. History of limb amputation (upper or lower extremity)
  9. 9. Planned surgery in the next 3 months.
  10. 10. History of chemotherapy or planned chemotherapy in the next 6 months or active malignancy.
  11. 11. Severe osteoporosis, defined by diagnosis of osteoporosis with fracture.
  12. 12. Pregnant or have a chance of being pregnant.
  13. 13. Chronic inflammatory condition, autoimmune disease or infectious processes such as active tuberculosis, Human Immunodeficiency Virus, Rheumatoid arthritis, systemic lupus erythematosus, acute or chronic hepatitis B or C.
  14. 14. Illicit drug use
  15. 15. Use of medications that may increase the risk of falling:
  16. * Sedatives
  17. * Hypnotics
  18. * Anti-cholinergic
  19. * Benzodiazepines
  20. * Anti-depressants
  21. 16. Intracranial bleeds visible on their most recent CT or MRI scans.

Contacts and Locations

Study Contact

Pranav J Parikh, MBBS, PhD
CONTACT
713-743-0503
pjparikh2@uh.edu

Study Locations (Sites)

The Center for Neuromotor and Biomechanics Research at the University of Houston
Houston, Texas, 77204
United States

Collaborators and Investigators

Sponsor: Weinberg Medical Physics LLC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-30
Study Completion Date2026-05-31

Study Record Updates

Study Start Date2025-04-30
Study Completion Date2026-05-31

Terms related to this study

Keywords Provided by Researchers

  • TMS
  • Balance
  • Brain stimulation
  • Elderly
  • Treatment

Additional Relevant MeSH Terms

  • Aging
  • Balance Deficits